INHA Monoclonal Antibody

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ProSci
Product Code: PSI-32-181
Product Group: Primary Antibodies
Supplier: ProSci
CodeSizePrice
PSI-32-181-0.1mg0.1mg£524.00
Quantity:
Prices exclude any Taxes / VAT

Overview

Host Type: Mouse
Antibody Isotype: IgG1
Antibody Clonality: Monoclonal
Antibody Clone: 4A2A9
Regulatory Status: RUO
Target Species: Human
Applications:
  • Enzyme-Linked Immunosorbent Assay (ELISA)
  • Immunohistochemistry (IHC)
  • Western Blot (WB)
Storage:
INHA(Inhibin alpha) monoclonal antibody can be stored at -20˚C, stable for one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Images

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Immunohistochemical analysis of paraffin - embedded human lymphoid tissue showing cytoplasmic and membrane location using INHA antibody with DAB staining.
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Immunohistochemical analysis of paraffin - embedded human lymphoid tissue showing cytoplasmic and membrane location using INHA antibody with DAB staining.

Documents

Further Information

Additional Names:
Inhibin alpha chain
Application Note:
Western Blot:1:500 - 1:1,000
IHC(P):1:1,000 - 1:2,000
ELISA:Propose dilution 1:10,000
Determining optimal working dilutions by titration test.
Background:
INHA(A-inhibin subunit precursor, inhibin alpha subunit ),also called inhibin(alpha) ,which is located on chromosome 2q33-q36. Inhibin is a gonadal protein that preferentially suppresses the secretion of pituitary follicle-stimulating hormone (FSH). Inhibin comprises of two subunits,Inhibin A and B. Inhibin has been shown to regulate gonadal stromal cell proliferation negatively and to have tumor suppressor activity. In addition, serum levels of inhibin have been shown to reflect the size of granulosa cell tumors and can therefore be used as a marker for primary as well as recurrent disease. In addition to their role in endocrine feedback in the reproductive sytem, inhibins subserve local regulatory roles in numerous extragonadal tissues, including brain, adrenal,bone marrow, placenta, and most notably anterior pituitary. Inhibin alpha subunit gene expression is down regulated in human prostate cancer, suggesting a tumor suppressive role.
Background References:
  • Mayo, K.E., Cerelli, G.M., Spiess, J., et al. 1986. Proc. Natl. Acad. Sci. USA 83: 5849-5853.
  • GM LM, WF Crowley, Jr, AL Schneyer.1995.J. Clin. Endocrinol. Metab., Oct . 80:3043-3049.
  • Knight, P.G. 1996.Front. Neuroendocrinol. 17: 476-509.
  • PA Fahy, CA Wilson, AJ Beard, et al. 1995.J Endocrinol Nov.147:271-283.
Buffer:
Ascitic fluid containing 0.03% sodium azide.
Concentration:
batch dependent
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Immunogen:
Ni-NTA purified truncated recombinant INHA expressed in E. Coli strain BL21 (DE3).
NCBI Gene ID #:
3623
NCBI Official Name:
inhibin, alpha
NCBI Official Symbol:
INHA
NCBI Organism:
Homo sapiens
Protein Accession #:
P05111
Protein GI Number:
124274
Purification:
Antibody is purified by protein A affinity chromatography.
Research Area:
Growth Factor
Swissprot #:
P05111
User NOte:
Optimal dilutions for each application to be determined by the researcher.