PRMT2 Antibody
| Code | Size | Price |
|---|
| PSI-29-206-100ul | 100ul | £609.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Rabbit
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Target Species:
- Human
- Mouse
- Rat
Applications:
- Enzyme-Linked Immunosorbent Assay (ELISA)
- Immunohistochemistry (IHC)
- Western Blot (WB)
Storage:
For short periods of storage (days) store at 4˚C. For longer periods of storage, store PRMT2 antibody at -20˚C. As with any antibody avoid repeat freeze-thaw cycles.
Documents
Further Information
Additional Names:
PRMT2, HRMT1L1
Application Note:
PRMT2 antibody can be used for detection of PRMT2 by ELISA at 1:1562500. PRMT2 antibody can be used for detection of PRMT2 by western blot at 0.625 μg/mL, and HRP conjugated secondary antibody should be diluted 1:50,000 - 100,000.
Background:
The protein arginine methyltransferases (PRMTs) include a family of proteins with related putative methyltransferase domains that modify chromatin and regulate cellular transcription. PRMT2 inhibits NF-kappaB-dependent transcription and promotes apoptosis and it exerts this effect by blocking nuclear export of IkappaB-alpha through a leptomycin-sensitive pathway, increasing nuclear IkappaB-alpha and decreasing NF-kappaB DNA binding. PRMT2 also rendered cells susceptible to apoptosis by cytokines or cytotoxic drugs, likely due to its effects on NF-kappaB.
Background References:
- Qi, C., (2002) J. Biol. Chem. 277 (32), 28624-28630.
Buffer:
Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
Concentration:
batch dependent
Conjugate:
Unconjugated
Immunogen:
Antibody produced in rabbits immunized with a synthetic peptide corresponding a region of human PRMT2.
NCBI Gene ID #:
3275
NCBI Official Name:
protein arginine methyltransferase 2
NCBI Official Symbol:
PRMT2
NCBI Organism:
Homo sapiens
Physical State:
Liquid
PREDICTED MOLECULAR WEIGHT:
48 kDa, 49 kDa
Protein Accession #:
NP_001526
Protein GI Number:
46255047
Purification:
Antibody is purified by protein A chromatography method.
Research Area:
Homeostasis
Swissprot #:
P55345
User NOte:
Optimal dilutions for each application to be determined by the researcher.