Caveolin-1 Antibody
| Code | Size | Price |
|---|
| PSI-79-548-0.1mg | 0.1mg | £481.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Rabbit
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Target Species:
- Human
- Mouse
- Rat
Application: Western Blot (WB)
Storage:
Store antibody at -20˚C for up to one year.
Documents
Further Information
Additional Names:
CGL3, PPH3, BSCL3, VIP21, MSTP085, CAV, CAV1
Application Note:
Western Blot: 1:500~1:1000
Background:
The scaffolding protein encoded by Caveolin-1 is the main component of the caveolae plasma membranes found in most cell types. The protein links integrin subunits to the tyrosine kinase FYN, an initiating step in coupling integrins to the Ras-ERK pathway and promoting cell cycle progression. The gene is a tumor suppressor gene candidate and a negative regulator of the Ras-p42/44 MAP kinase cascade. CAV1 and CAV2 are located next to each other on chromosome 7 and express colocalizing proteins that form a stable hetero-oligomeric complex. By using alternative initiation codons in the same reading frame, two isoforms (alpha and beta) are encoded by a single transcript from this gene.
Background References:
- Zhang Y, et al. (2005) Mol Cell Proteomics. 4 (9): 1240-1250. Labrecque L, et al. (2004) J Biol Chem. 279 (50): 52132-52140. Fielding PE, et al. (2004) Biochemistry. 43 (9): 2578-2586. Labrecque L, et al. (2003) Mol Biol Cell. 14 (1): 334-347. Maggi D, et al. (2002) Biochem Biophys Res Commun. 295 (5): 1085-1089.
Buffer:
Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Concentration:
1 mg/mL
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Immunogen:
Caveolin-1 (Ab-14) antibody was raised against a peptide sequence around aa.12~16 (H-L-Y-T-V) derived from Human CAVEOLIN-1.
NCBI Gene ID #:
857
NCBI Official Name:
caveolin 1, caveolae protein, 22kDa
NCBI Official Symbol:
CAV1
NCBI Organism:
Homo sapiens
Physical State:
Liquid
PREDICTED MOLECULAR WEIGHT:
24 kDa
Protein Accession #:
NP_001166366.1
Protein GI Number:
290542359
Purification:
Antibodies were purified by affinity-chromatography using epitope-specific peptide.
Research Area:
Cell Cycle
SPECIFICITY:
This antibody detects endogenous level of total Caveolin-1 protein.
Swissprot #:
Q03135