CK2a Antibody
| Code | Size | Price |
|---|
| PSI-79-519-0.1mg | 0.1mg | £488.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Rabbit
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Target Species:
- Human
- Mouse
- Rat
Application: Western Blot (WB)
Storage:
Store antibody at -20˚C for up to one year.
Documents
Further Information
Additional Names:
CAP102, P53, CKII, CK2A1, CSNK2A1
Application Note:
Western Blot: 1:1000
Background:
Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. The alpha and alpha' chains contain the catalytic site. Participates in Wnt signaling. CK2 phosphorylates 'Ser-392' of p53/TP53 following UV irradiation.
Background References:
- Keller D. M., Zeng X., et al., Mol. Cell 7:283-292 (2001) Keller D. M., Lu H. et al., J. Biol. Chem. 277:50206-50213 (2002) Trembley J. H., Tatsumi S., et al., Mol. Cell. Biol. 25:1446-1457 (2005) Niefind K., Guerra B., et al., Acta Crystallogr. D 56:1680-1684 (2000)
Buffer:
Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Concentration:
1 mg/mL
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Immunogen:
CK2a (phospho-Thr360/Ser362) antibody was raised against a peptide sequence around phosphorylation site of threonine360/serine 362 (V-P-T (p) -P-S (p) -P-L) derived from Human CK2α.
Modifications:
Phospho-Specific
NCBI Gene ID #:
1495
NCBI Official Name:
catenin (cadherin-associated protein), alpha 1, 102kDa
NCBI Official Symbol:
CTNNA1
NCBI Organism:
Homo sapiens
Physical State:
Liquid
PREDICTED MOLECULAR WEIGHT:
42 kDa
Protein Accession #:
NP_001894.2
Protein GI Number:
55770844
Purification:
Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy using non-phosphopeptide.
Research Area:
Phospho-Specific
SPECIFICITY:
This antibody detects endogenous level of CK2 only when phosphorylated at thronine 360.
Swissprot #:
P68400