Glutamate receptor 2 Antibody

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ProSci
Product Code: PSI-79-494
Product Group: Primary Antibodies
Supplier: ProSci
CodeSizePrice
PSI-79-494-0.1mg0.1mg£488.00
Quantity:
Prices exclude any Taxes / VAT

Overview

Host Type: Rabbit
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Target Species:
  • Human
  • Mouse
  • Rat
Application: Western Blot (WB)
Storage:
Store antibody at -20˚C for up to one year.

Images

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Western blot analysis of lysed extracts from mouse brain tissue using Glutamate receptor 2 (Precursor) (phospho-Ser880).
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Western blot analysis of lysed extracts from mouse brain tissue using Glutamate receptor 2 (Precursor) (phospho-Ser880).

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Further Information

Additional Names:
GLUR2, GLURB, GluA2, HBGR2, GluR-K2, PI12, GRIA2, GluR-2, GluR-B, AMPA 2
Application Note:
Western Blot: 1:500~1:1000
Background:
Ionotropic glutamate receptor. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. Binding of the excitatory neurotransmitter L-glutamate induces a conformation change, leading to the opening of the cation channel, and thereby converts the chemical signal to an electrical impulse. The receptor then desensitizes rapidly and enters a transient inactive state, characterized by the presence of bound agonist.
Background References:
  • Cull-Candy, S. et al. (2006) Curr. Opin. Neurobiol. 16, 288-297. Hanley JG, et al. (2002) Neuron. 34 (1): 53-67
Buffer:
Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Concentration:
1 mg/mL
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Immunogen:
Glutamate receptor 2 (Precursor) (phospho-Ser880) antibody was raised against a peptide sequence around phosphorylation site of serine 880 (I-E-S (p) -V-K) derived from Human Glutamate receptor 2.
Modifications:
Phospho-Specific
NCBI Gene ID #:
2891
NCBI Official Name:
glutamate receptor, ionotropic, AMPA 2
NCBI Official Symbol:
GRIA2
NCBI Organism:
Homo sapiens
Physical State:
Liquid
PREDICTED MOLECULAR WEIGHT:
100 kDa
Protein Accession #:
NP_000817.2
Protein GI Number:
74275354
Purification:
Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy using non-phosphopeptide.
Research Area:
Phospho-Specific,Neuroscience
SPECIFICITY:
This antibody detects endogenous level of Glutamate receptor 2 (Precursor) only when phosphorylated at serine 880.
Swissprot #:
P42262