HDAC4 Antibody
| Code | Size | Price |
|---|
| PSI-79-468-0.1mg | 0.1mg | £488.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Rabbit
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Target Species:
- Human
- Mouse
- Rat
Application: Western Blot (WB)
Storage:
Store antibody at -20˚C for up to one year.
Documents
Further Information
Additional Names:
HD4, AHO3, BDMR, HDACA, HA6116, HDAC-4, HDAC-A, AML1, CBFA2, HD4
Application Note:
Western Blot: 1:500~1:1000
Background:
Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Involved in muscle maturation via its interaction with the myocyte enhancer factors such as MEF2A, MEF2C and MEF2D.
Background References:
- Wang AH, et al. (2000) Mol Cell Biol. 20 (18): 6904-6912. Grozinger CM, et al. (2000) Proc Natl Acad Sci U S A. 97 (14): 7835-7840.
Buffer:
Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Concentration:
1 mg/mL
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Immunogen:
HDAC4 (Phospho-Ser632) antibody was raised against a peptide sequence around phosphorylation site of serine 632 (A-Q-S (p) -S-P) derived from Human HDAC4.
Modifications:
Phospho-Specific
NCBI Gene ID #:
9759
NCBI Official Name:
histone deacetylase 4
NCBI Official Symbol:
HDAC4
NCBI Organism:
Homo sapiens
Physical State:
Liquid
PREDICTED MOLECULAR WEIGHT:
140 kDa
Protein Accession #:
NP_006028.2
Protein GI Number:
153085395
Purification:
Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy using non-phosphopeptide.
Research Area:
Phospho-Specific,Cell Cycle
SPECIFICITY:
This antibody detects endogenous level of HDAC4 only when phosphorylated at serine 632.
Swissprot #:
P56524