IGF-1R Antibody

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ProSci
Product Code: PSI-79-407
Product Group: Primary Antibodies
Supplier: ProSci
CodeSizePrice
PSI-79-407-0.1mg0.1mg£481.00
Quantity:
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Overview

Host Type: Rabbit
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Target Species:
  • Human
  • Mouse
  • Rat
Applications:
  • Immunohistochemistry (IHC)
  • Western Blot (WB)
Storage:
Store antibody at -20˚C for up to one year.

Images

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Western blot analysis of lysed extracts from 293, 3T3 and HeLa cells using IGF-1R (Ab-1280).
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Immunohistochemical analysis of paraffin-embedded human breast carcinoma tissue using IGF-1R (Ab-1280).
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Western blot analysis of lysed extracts from 293, 3T3 and HeLa cells using IGF-1R (Ab-1280).
Immunohistochemical analysis of paraffin-embedded human breast carcinoma tissue using IGF-1R (Ab-1280).

Documents

Further Information

Additional Names:
IGFR, CD221, IGFIR, JTK13, PDGFR, PDGFR1, Insulin-like growth factor I receptor
Application Note:
Western Blot: 1:500~1:1000, Immunohistochemistry: 1:50~1:100
Background:
This receptor binds insulin-like growth factor 1 (IGF1) with a high affinity and IGF2 with a lower affinity. It has a tyrosine-protein kinase activity, which is necessary for the activation of the IGF1-stimulated downstream signaling cascade. When present in a hybrid receptor with INSR, binds IGF1.
Background References:
  • Adams, T. E. et al. (2000) Cell. Mol. Life Sci. 57, 1050-1093Baserga, R. et al. (2000) Oncogene 19, 5574-5581Scheidegger, K. J. et al. (2000) J. Biol. Chem. 275, 38921-38928. O'Connor R, et al. Mol Cell Biol 1997 Jan; 17 (1): 427-35
Buffer:
Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Concentration:
1 mg/mL
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Immunogen:
IGF-1R (Ab-1280) antibody was raised against a peptide sequence around aa. 1278~1282 (S-F-Y-Y-S ) derived from Human IGF-1R .
NCBI Gene ID #:
3480
NCBI Official Name:
insulin-like growth factor 1 receptor
NCBI Official Symbol:
IGF1R
NCBI Organism:
Homo sapiens
Physical State:
Liquid
PREDICTED MOLECULAR WEIGHT:
200, 95 kDa
Protein Accession #:
NP_000866.1
Protein GI Number:
4557665
Purification:
Antibodies were purified by affinity-chromatography using epitope-specific peptide.
Research Area:
Other
SPECIFICITY:
This antibody detects endogenous level of total IGF-1R protein.
Swissprot #:
P08069