MBP Antibody
| Code | Size | Price |
|---|
| PSI-79-741-0.1mg | 0.1mg | £481.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Rabbit
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Target Species:
- Human
- Mouse
- Rat
Application: Western Blot (WB)
Storage:
Store antibody at -20˚C for up to one year.
Documents
Further Information
Additional Names:
MGC99675
Application Note:
Western Blot: 1:500~1:1000
Background:
The classic group of MBP isoforms (isoform 4-isoform 14) are with PLP the most abundant protein components of the myelin membrane in the CNS. They have a role in both its formation and stabilization. The smaller isoforms might have an important role in remyelination of denuded axons in multiple sclerosis. The non-classic group of MBP isoforms (isoform 1-isoform 3/Golli-MBPs) may preferentially have a role in the early developing brain long before myelination, maybe as components of transcriptional complexes, and may also be involved in signaling pathways in T-cells and neural cells. Differential splicing events combined with optional post-translational modifications give a wide spectrum of isomers, with each of them potentially having a specialized function. Induces T-cell proliferation.
Background References:
- Pribyl T. M., Campagnoni C. W., Kampf K., Kashima T., Handley V. W., McMahon J., Campagnoni A. T. Proc. Natl. Acad. Sci. U. S. A. 90:10695-10699 (1993) Nye S. H., Pelfrey C. M., Burkwit J. J., Voskuhl R. R., Lenardo M. J., Mueller J. P. Mol. Immunol. 32:1131-1141 (1995)
Buffer:
Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Concentration:
1 mg/mL
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Immunogen:
MBP (myelin basic protein) antibody was raised against a peptide sequence around aa.291~295 (G-G-R-D-S) derived from Human MBP.
NCBI Gene ID #:
4155
NCBI Official Name:
myelin basic protein
NCBI Official Symbol:
MBP
NCBI Organism:
Homo sapiens
Physical State:
Liquid
PREDICTED MOLECULAR WEIGHT:
14~33 kDa
Protein Accession #:
NP_001020252.1
Protein GI Number:
68509930
Purification:
Antibodies were purified by affinity-chromatography using epitope-specific peptide.
Research Area:
Neuroscience
SPECIFICITY:
This antibody detects endogenous level of total MBP(myelin basic protein) protein.
Swissprot #:
P02686