Apoa5 (bd) Monoclonal Antibody
| Code | Size | Price |
|---|
| PSI-32-110-0.1mg | 0.1mg | £657.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Mouse
Antibody Isotype: IgG1
Antibody Clonality: Monoclonal
Antibody Clone: 4H8H8E2c
Regulatory Status: RUO
Target Species: Human
Applications:
- Enzyme-Linked Immunosorbent Assay (ELISA)
- Western Blot (WB)
Storage:
Apoa5(bd) monoclonal antibody can be stored at -20˚C, stable for one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Documents
Further Information
Additional Names:
RAP3, UNQ411/PRO773, Apolipoprotein A5, Apo-AV, RAP3, APOAV
Application Note:
Western Blot, ELISA.
Dilution:
Western Blot:1:500 - 1,000
ELISA:Determining optimal working dilutions by titration test.
Dilution:
Western Blot:1:500 - 1,000
ELISA:Determining optimal working dilutions by titration test.
Background:
Apolipoprotein A5 (ApoA5) is fast gaining attention as a key regulator of serum triglyceride concentrations. An ApoA5 mouse knock-out model produced an approximately four fold increase in serum triglyc erides, whereas a knock-in model with human ApoA5 produced 50?70% lower concentrations of mouse serum triglycerides. In addition, peroxisome proliferator-activated receptor-_ agonists, which are used clinically to lower serum triglyceride concentrations, cause increased ApoA5 mRNA expression. Recently, it was demonstrated that ApoA5 is present in human serum detected by polyclonal antibodies against both the NH2 and COOH termini, although at much lower concentration than other apolipoproteins.
Background References:
- Pennacchio, L. et al. Science 2001 294, 169-173.
- Prieur, X. et al. (2003) J Biol Chem 278, 25468-25480.
- Obrien, PJ. et al. (2005) Clin Chem 51:2, 1-9.
Buffer:
Ascitic fluid containing 0.03% sodium azide.
Concentration:
batch dependent
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Immunogen:
Ni-NTA purified truncated recombinant human APOA5 expressed in E. Coli strain BL21 (DE3).
NCBI Gene ID #:
116519
NCBI Official Name:
apolipoprotein A-V
NCBI Official Symbol:
APOA5
NCBI Organism:
Homo sapiens
Protein Accession #:
Q6Q788
Protein GI Number:
60391728
Research Area:
Signal Transduction
Swissprot #:
Q6Q788
User NOte:
Optimal dilutions for each application to be determined by the researcher.