p95/NBS1 Antibody

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ProSci
Product Code: PSI-79-440
Product Group: Primary Antibodies
Supplier: ProSci
CodeSizePrice
PSI-79-440-0.1mg0.1mg£488.00
Quantity:
Prices exclude any Taxes / VAT

Overview

Host Type: Rabbit
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Target Species:
  • Human
  • Mouse
  • Rat
Application: Western Blot (WB)
Storage:
Store antibody at -20˚C for up to one year.

Images

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Western blot analysis of lysed extracts from HeLa cells untreated or treated with Hydroxyurea using p95/NBS1 (Phospho-Ser343).
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Western blot analysis of lysed extracts from HeLa cells untreated or treated with Hydroxyurea using p95/NBS1 (Phospho-Ser343).

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Further Information

Additional Names:
ATV, NBS, P95, NBS1, AT-V1, AT-V2, TCF5, PP9092,
Application Note:
Western Blot: 1:500~1:1000
Background:
Mutations in p95/NBS1 gene are associated with Nijmegen breakage syndrome, an autosomal recessive chromosomal instability syndrome characterized by microcephaly, growth retardation, immunodeficiency, and cancer predisposition. The encoded protein is a member of the MRE11/RAD50 double-strand break repair complex which consists of 5 proteins. This gene product is thought to be involved in DNA double-strand break repair and DNA damage-induced checkpoint activation.
Background References:
  • Hsu HL, et al (2005) Oncogene; 24 (31): 4956-64. Falck J, et al. (2005) Nature; 434 (7033): 605-11. Buscemi G, et al. (2004) Oncogene; 23 (46): 7691-700. Beausoleil SA, et al. (2004) Proc Natl Acad Sci U S A; 101 (33): 12130-5.
Buffer:
Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Concentration:
1 mg/mL
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Immunogen:
p95/NBS1 (Phospho-Ser343) antibody was raised against a peptide sequence around phosphorylation site of serine 343 (S-L-S (p) -Q-G) derived from Human p95/NBS1.
Modifications:
Phospho-Specific
NCBI Gene ID #:
4683
NCBI Official Name:
nibrin
NCBI Official Symbol:
NBN
NCBI Organism:
Homo sapiens
Physical State:
Liquid
PREDICTED MOLECULAR WEIGHT:
95 kDa
Protein Accession #:
NP_002476.2
Protein GI Number:
33356172
Purification:
Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy using non-phosphopeptide.
Research Area:
Phospho-Specific,Cell Cycle
SPECIFICITY:
This antibody detects endogenous level of p95/NBS1 only when phosphorylated at serine 343.
Swissprot #:
O60934