TrkA Antibody
| Code | Size | Price |
|---|
| PSI-79-501-0.1mg | 0.1mg | £488.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Rabbit
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Target Species: Human
Applications:
- Immunofluorescence (IF)
- Western Blot (WB)
Storage:
Store antibody at -20˚C for up to one year.
Documents
Further Information
Additional Names:
MTC, TRK, TRK1, TRKA, Trk-A, p140-TrkA, MGF, SCF, High affinity nerve growth factor receptor precursor, NTRK1, Slow nerve growth factor receptor, TRK1 transforming tyrosine kinase protein
Application Note:
Western Blot: 1:500~1:1000, Immunofluorescence: 1:100~1:200
Background:
Required for high-affinity binding to nerve growth factor (NGF), neurotrophin-3 and neurotrophin-4/5 but not brain-derived neurotrophic factor (BDNF). Known substrates for the Trk receptors are SHC1, PI 3-kinase, and PLC γ1. Has a crucial role in the development and function of the nociceptive reception system as well as establishment of thermal regulation via sweating. Activates ERK1 by either SHC1- or PLC γ1-dependent signaling pathway.
Background References:
- Wiese S, et al. Proc Natl Acad Sci U S A. 2007 Oct 23; 104 (43): 17210-5. Valdez G, et al. Proc Natl Acad Sci U S A. 2007 Jul 24;104 (30): 12270-5Inoue K, et al. J Biol Chem. 2007 Aug 17;282 (33): 24175-84
Buffer:
Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Concentration:
1 mg/mL
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Immunogen:
TrkA (Phospho-Ser791) antibody was raised against a peptide sequence around phosphorylation site of tyrosine791 (P-V-Y (p) -L-D) derived from Human TrkA.
Modifications:
Phospho-Specific
NCBI Gene ID #:
4914
NCBI Official Name:
neurotrophic tyrosine kinase, receptor, type 1
NCBI Official Symbol:
NTRK1
NCBI Organism:
Homo sapiens
Physical State:
Liquid
PREDICTED MOLECULAR WEIGHT:
140 kDa
Protein Accession #:
NP_001007793.1
Protein GI Number:
56118210
Purification:
Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy using non-phosphopeptide.
Research Area:
Phospho-Specific,Neuroscience
SPECIFICITY:
This antibody detects endogenous level of TrkA only when phosphorylated at tyrosine 791.
Swissprot #:
P04629