Tyrosine Hydroxylase Antibody
| Code | Size | Price |
|---|
| PSI-79-474-0.1mg | 0.1mg | £488.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Rabbit
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Target Species:
- Human
- Mouse
- Rat
Application: Immunofluorescence (IF)
Storage:
Store antibody at -20˚C for up to one year.
Documents
Further Information
Additional Names:
TYH, DYT14, DYT5b, MAPTL, MTBT1, TAU, TY3H, TYH, Tyrosine 3-hydroxylase, tyrosine hydroxylase
Application Note:
Immunofluorescence: 1:100~1:200
Background:
The protein encoded by Tyrosine Hydroxylase is involved in the conversion of tyrosine to dopamine. It is the rate-limiting enzyme in the synthesis of catecholamines, hence plays a key role in the physiology of adrenergic neurons. Mutations in this gene have been associated with autosomal recessive Segawa syndrome. Alternatively spliced transcript variants encoding different isoforms have been noted for this gene.
Background References:
- Vazin T, et al. Stem Cells. 2008 Jun;26 (6): 1517-25Pistocchi A, et al. BMC Dev Biol. 2008 Mar 10;8:27 Fukakusa A, et al. J Pharmacol Sci. 2008 Feb;106 (2): 321-4.
Buffer:
Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Concentration:
1 mg/mL
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Immunogen:
Tyrosine Hydroxylase (Phospho-Ser40) antibody was raised against a peptide sequence around phosphorylation site of serine 40 (R-Q-S (p) -L-I) derived from Human Tyrosine Hydroxylase (TH).
Modifications:
Phospho-Specific
NCBI Gene ID #:
7054
NCBI Official Name:
tyrosine hydroxylase
NCBI Official Symbol:
TH
NCBI Organism:
Homo sapiens
Physical State:
Liquid
PREDICTED MOLECULAR WEIGHT:
55 - 60 kDa
Protein Accession #:
NP_000351.2
Protein GI Number:
88900503
Purification:
Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy using non-phosphopeptide.
Research Area:
Phospho-Specific,Neuroscience
SPECIFICITY:
This antibody detects endogenous level of TyrosineHydroxylase only when phosphorylated at serine 40.
Swissprot #:
P07101?