p62Dok Antibody
| Code | Size | Price |
|---|
| PSI-79-223-0.1mg | 0.1mg | £488.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Rabbit
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Target Species:
- Human
- Mouse
- Rat
Applications:
- Immunohistochemistry (IHC)
- Western Blot (WB)
Storage:
Store antibody at -20˚C for up to one year.
Documents
Further Information
Additional Names:
P62DOK, PRKCT, DOK1
Application Note:
Western Blot: 1:500~1:1000, Immunohistochemistry: 1:50~1:100
Background:
DOK proteins are enzymatically inert adaptor or scaffolding proteins. They provide a docking platform for the assembly of multimolecular signaling complexes. DOK1 appears to be a negative regulator of the insulin signaling pathway. Modulates integrin activation by competing with talin for the same binding site on ITGB3.
Background References:
- Zhou Songyang, et al. (2001) J. Biol. Chem ; 276: 2459 - 2465. Jean-Guy Nemorin, et al. (2000) J. Biol. Chem ; 275: 14590. Yuji Yamanashi, et al. (2000) Genes & Dev ; 14: 11. Ibuki Kato, et al. (2002) J. Immunol ; 168: 629.
Buffer:
Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Concentration:
1 mg/mL
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Immunogen:
p62Dok (phospho-Tyr362) antibody was raised against a peptide sequence around phosphorylation site of tyrosine 362 (P-I-Y (p) -D-E) derived from Human p62Dok.
Modifications:
Phospho-Specific
NCBI Gene ID #:
1796
NCBI Official Name:
docking protein 1, 62kDa (downstream of tyrosine kinase 1)
NCBI Official Symbol:
DOK1
NCBI Organism:
Homo sapiens
Physical State:
Liquid
PREDICTED MOLECULAR WEIGHT:
62 kDa
Protein Accession #:
NP_001372.1
Protein GI Number:
4503357
Purification:
Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy using non-phosphopeptide.
Research Area:
Phospho-Specific
SPECIFICITY:
This antibody detects endogenous level of p62Dok only when phosphorylated at tyrosine 362.
Swissprot #:
Q99704