TAO2 Antibody
| Code | Size | Price |
|---|
| PSI-XPS-1029-0.1mL | 0.1mL | £686.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Rabbit
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Target Species:
- Human
- Mouse
- Rat
Application: Western Blot (WB)
Storage:
For long term storage ?80˚C is recommended, but shorter term storage at ?20˚C is also acceptable as aliquots may be taken without freeze/thawing due to the presence of 50% glycerol. Stable for one year.
Documents
Further Information
Application Note:
Human, mouse, rat and Xenopus have 100% amino acid sequence identity with the antigen used to raise the antibody. Applications include Dot Blots (DB) and Western Blots (WB). Suitability for Immunohistochemistry (IHC) has not been determined. When internally tested under ideal conditions the working dilutions were 1:1000 for DB and WB.
Background:
TAO (thousand and one amino acid) protein kinases mediate signaling from carbachol to p38 MAPK and ternary complex transcription factors. This has led to the proposal that the TAO protein kinases play an essential role in signaling from physiological agonists to the stress-responsive p38 MAPKs. Autophosphorylation of TAO may play a role in the mechanism of TAO activation. The MEK binding domain of TAO is autophosphorylated on both serine and threonine residues and Ser181 is located within this domain.
Background References:
- Chen, z., Raman, M., Chen, L., Lee, S.F., Gilman, A.G., and Cobb, M.H., "TAO (thousand-and-one amino acid) protein kinases mediate signaling from carbachol to p38 mitogen-activated protein kinase and ternary complex factors," J. Biol. Chem. 278 (2003) 22,278-22,283.
- Chen z., and Cobb, M.H., "Regulation of stress-responsive mitogen-activated protein (MAP) kinase pathways by TAO2", J. Biol. Chem. 276 (2001) 16,070-16,075.
- Chen, Z., Hutchison, M., and Cobb, M.H., "Isolation of the protein kinase TAO2 and identification of its mitogen-activated protein kinase/extracellular signal-regulated kinase kinase binding domain," J. Biol. Chem. 274 (1999) 28,803-28,807.
Concentration:
batch dependent
Conjugate:
Unconjugated
Immunogen:
TAO2 (Ser181) polyclonal antibody was raised against a synthetic phosphopeptide corresponding to amino acids residues surrounding the phospho Ser181 of TAO2.
Modifications:
Phospho-Specific
NCBI Gene ID #:
9344
NCBI Official Name:
TAO kinase 2
NCBI Official Symbol:
TAOK2
NCBI Organism:
Homo sapiens
Physical State:
Liquid
PREDICTED MOLECULAR WEIGHT:
120
Protein Accession #:
Q9UL54
Protein GI Number:
116242813
Purification:
Affinity Purified
Research Area:
Signal Transduction ,Phospho-Specific
SPECIFICITY:
TAO2 antibody is specific for Mr ~120k TAO2 phosphorylated at Ser181.
Swissprot #:
Q9UL54
User NOte:
Optimal dilutions for each application to be determined by the researcher.