LDLR Antibody
| Code | Size | Price |
|---|
| PSI-XW-7339-0.05mg | 0.05mg | £801.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Chicken
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Target Species:
- Human
- Mouse
- Rat
Application: Western Blot (WB)
Storage:
LDLR antibody can be stored at 4˚C for short term (weeks). Long term storage should be at -20˚C. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Documents
Further Information
Additional Names:
Low-density lipoprotein receptorLDL receptor, FH, FHC, LDLCQ2, LDLR
Application Note:
LDL-R antibody can be used for the detection of LDL-R by Western blot, may also work for IHC and ICC.
Background:
Low density lipoprotein receptor. The low density lipoprotein receptor (LDLR) gene family consists of cell surface proteins involved in receptor-mediated endocytosis of specific ligands. Low density lipoprotein (LDL) is normally bound at the cell membrane and taken into the cell ending up in lysosomes where the protein is degraded and the cholesterol is made available for repression of microsomal enzyme 3-hydroxy-3-methylglutaryl coenzyme A (HMG CoA) reductase, the rate-limiting step in cholesterol synthesis. At the same time, a reciprocal stimulation of cholesterol ester synthesis takes place. Mutations in this gene cause the autosomal dominant disorder, familial hypercholesterolemia.
Background References:
- Agnello, V., Abel, G., Elfahal, M., Knight, G. B., Zhang, Q. -X. Hepatitis C virus and other flaviviridae viruses enter cells via low density lipoprotein receptor. Proc. Nat. Acad. Sci. 96: 12766-12771, 1999.
Buffer:
Phosphate-Buffered Saline. No preservatives added.
Concentration:
1 mg/mL
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Immunogen:
29-205
NCBI Gene ID #:
3949
NCBI Official Name:
low density lipoprotein receptor
NCBI Official Symbol:
LDLR
NCBI Organism:
Homo sapiens
Physical State:
Liquid
PREDICTED MOLECULAR WEIGHT:
95.4 kDa (calculated)
Protein Accession #:
NP_000518.1
Protein GI Number:
4504975
Purification:
Antigen affinity-purified
Research Area:
Signal Transduction, Obesity ,
Swissprot #:
P01130
User NOte:
Optimal dilutions for each application to be determined by the researcher.