APAF1 Antibody
| Code | Size | Price |
|---|
| PSI-XW-7034-0.05mg | 0.05mg | £801.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Chicken
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Target Species:
- Human
- Mouse
Application: Western Blot (WB)
Storage:
APAF1 antibody can be stored at 4˚C for short term (weeks). Long term storage should be at -20˚C. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Documents
Further Information
Additional Names:
KIAA0413, Apoptotic protease-activating factor 1APAF-1, CED4, APAF-1,
Application Note:
Apaf-1 antibody can be used for the detection of Apaf-1 by Western blot, may also work for IHC and ICC.
Background:
Apoptotic protease activating factor 1. Apaf-1 is a cytoplasmic protein that initiates apoptosis. This protein contains several copies of the WD-40 domain, a caspase recruitment domain (CARD), and an ATPase domain (NB-ARC). Upon binding cytochrome c and dATP, this protein forms an oligomeric apoptosome. The apoptosome binds and cleaves caspase 9 preproprotein, releasing its mature, activated form. Activated caspase 9 stimulates the subsequent caspase cascade that commits the cell to apoptosis. Alternative splicing results in several transcript variants encoding different isoforms.
Background References:
- Cecconi,F., Alvarez-Bolado,G., Meyer,B. I., Roth,K. A. and Gruss,P. Apaf1 (CED-4 homolog) regulates programmed cell death in mammalian development. Cell 94 (6), 727-737 (1998),
Buffer:
Phosphate-Buffered Saline. No preservatives added.
Concentration:
1 mg/mL
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Immunogen:
307-388
NCBI Gene ID #:
317
NCBI Official Name:
apoptotic peptidase activating factor 1
NCBI Official Symbol:
APAF1
NCBI Organism:
Homo sapiens
Physical State:
Liquid
PREDICTED MOLECULAR WEIGHT:
141.8 kDa (calculated)
Protein Accession #:
NP_863658.1
Protein GI Number:
32483361
Purification:
Antigen affinity-purified
Research Area:
Apoptosis, Cancer
Swissprot #:
O14727
User NOte:
Optimal dilutions for each application to be determined by the researcher.