PTPRC Antibody
| Code | Size | Price |
|---|
| PSI-XW-7814-0.05mg | 0.05mg | £765.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Chicken
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Target Species: Human
Application: Western Blot (WB)
Storage:
PTPRC antibody can be stored at 4˚C for short term (weeks). Long term storage should be at -20˚C. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Documents
Further Information
Additional Names:
CD45, Receptor-type tyrosine-protein phosphatase C, Leukocyte common antigen, L-CA, LCA, LY5, B220, CD45, T200, CD45R, GP180, CD45 antigen
Application Note:
Leukocyte common antigen antibody can be used for the detection of Leukocyte common antigen by Western Blot.
Background:
FUNCTION: Required for T-cell activation through the antigen receptor. The first PTPase domain has enzymatic activity, while the second one seems to affect the substrate specificity of the first one.
DISEASE: Defects in PTPRC are a cause of autosomal recessive severe combined immunodeficiency T cell-negative/B cell-positive/NK cell-positive (T(-)/B(+)/NK(+) SCID) [MIM:608971]. SCID refers to a genetically and clinically group of rare congenital disorders characterized by impairment of both humoral and cell-mediated immunity, leukopenia, and low or absent antibody levels. Patients with SCID present in infancy with recurrent, persistent infections by opportunistic organisms, including Candida albicans, Pneumocystis carinii, and cytomegalovirus, among many others. The common characteristic of all types of SCID is absence of T cell-mediated cellular immunity due to a defect in T-cell development.
DISEASE: Defects in PTPRC are a cause of autosomal recessive severe combined immunodeficiency T cell-negative/B cell-positive/NK cell-positive (T(-)/B(+)/NK(+) SCID) [MIM:608971]. SCID refers to a genetically and clinically group of rare congenital disorders characterized by impairment of both humoral and cell-mediated immunity, leukopenia, and low or absent antibody levels. Patients with SCID present in infancy with recurrent, persistent infections by opportunistic organisms, including Candida albicans, Pneumocystis carinii, and cytomegalovirus, among many others. The common characteristic of all types of SCID is absence of T cell-mediated cellular immunity due to a defect in T-cell development.
Buffer:
Phosphate-Buffered Saline. No preservatives added.
Concentration:
1 mg/mL
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Immunogen:
482-552
NCBI Gene ID #:
5788
NCBI Official Name:
protein tyrosine phosphatase, receptor type, C
NCBI Official Symbol:
PTPRC
NCBI Organism:
Homo sapiens
Physical State:
Liquid
PREDICTED MOLECULAR WEIGHT:
147.3 kDa (calculated)
Protein Accession #:
NP_002829.2
Protein GI Number:
18641347
Purification:
Immunoaffinity Purified
Swissprot #:
P08575
User NOte:
Optimal dilutions for each application to be determined by the researcher.