SETD7 Antibody
| Code | Size | Price |
|---|
| PSI-30-476-100ul | 100ul | £609.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Rabbit
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Target Species:
- Human
- Mouse
- Rat
Applications:
- Enzyme-Linked Immunosorbent Assay (ELISA)
- Western Blot (WB)
Storage:
For short periods of storage (days) store at 4˚C. For longer periods of storage, store SETD7 antibody at -20˚C. As with any antibody avoid repeat freeze-thaw cycles.
Documents
Further Information
Additional Names:
SETD7, FLJ21193, KIAA1717, KMT7, SET7, SET7/9, SET9
Application Note:
SETD7 antibody can be used for detection of SETD7 by ELISA at 1:312500. SETD7 antibody can be used for detection of SETD7 by western blot at 5.0 μg/mL, and HRP conjugated secondary antibody should be diluted 1:50,000 - 100,000.
Background:
SETD7 is a histone methyltransferase that specifically monomethylates 'Lys-4' of histone H3. H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation. It plays a central role in the transcriptional activation of genes such as collagenase or insulin. It is recruited by IPF1/PDX-1 to the insulin promoter, leading to activate transcription. It has also methyltransferase activity toward non-histone proteins such as p53/TP53, TAF10, and possibly TAF7 by recognizing and binding the [KR]-[STA]-K in substrate proteins.
Background References:
- Subramanian, K., (2008) Mol. Cell 30 (3), 336-347.
Buffer:
Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
Concentration:
batch dependent
Conjugate:
Unconjugated
Immunogen:
Antibody produced in rabbits immunized with a synthetic peptide corresponding a region of human SETD7.
NCBI Gene ID #:
80854
NCBI Official Name:
SET domain containing (lysine methyltransferase) 7
NCBI Official Symbol:
SETD7
NCBI Organism:
Homo sapiens
Physical State:
Liquid
PREDICTED MOLECULAR WEIGHT:
41 kDa
Protein Accession #:
NP_085151
Protein GI Number:
18139549
Purification:
Antibody is purified by protein A chromatography method.
Research Area:
Cancer
Swissprot #:
Q8WTS6
User NOte:
Optimal dilutions for each application to be determined by the researcher.