MCP-1 Monoclonal Antibody
| Code | Size | Price |
|---|
| PSI-32-230-0.1mg | 0.1mg | £524.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Mouse
Antibody Isotype: IgG1.kappa
Antibody Clonality: Monoclonal
Antibody Clone: 1A7B8
Regulatory Status: RUO
Target Species: Human
Applications:
- Enzyme-Linked Immunosorbent Assay (ELISA)
- Western Blot (WB)
Storage:
to MCP-1 monoclonal antibody can be stored at -20˚C, stable for one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Documents
Further Information
Additional Names:
MCP1, SCYA2, HC11, MCAF, MCP1, MCP-1, GDCF-2, SMC-CF, HSMCR30
Application Note:
Western Blot:1:500 - 1,000
ELISA:1,000 - 2,000.
ELISA:1,000 - 2,000.
Background:
Monocyte chemoattractant protein-1 (MCP-1) is a member of the chemokine-beta family of cytokines. The protein is structurally related to the CXC subfamily of cytokines. Members of this subfamily are characterized by two cysteines separated by a single amino acid. This cytokine displays chemotactic activity for monocytes and basophils but not for neutrophils or eosinophils. It has been implicated in the pathogenesis of diseases characterized by monocytic infiltrates, like psoriasis, rheumatoid arthritis and atherosclerosis. It binds to chemokine receptors CCR2 and CCR4. It may play a inprotant role in the initiation and/or progression of pulmonary hypertension (PH). Blockade of a systemic MCP-1 signal pathway in vivo may prevent PH.
Background References:
- Yoshimura T. et al. 1989. FEBS Lett. 244:487-493.
- Yoshimura T. et al. 1991. Adv. Exp. Med. Biol. 305:47-56.
- Rollins B.J. et al. 1991. Genomics. 10:489-492.
Buffer:
Purified antibody in PBS containing 0.03% sodium azide.
Concentration:
batch dependent
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Immunogen:
Ni-NTA purified recombinant human MCP-1 expressed in E.Coli strain BL21 (DE3).
NCBI Gene ID #:
6347
NCBI Official Name:
chemokine (C-C motif) ligand 2
NCBI Official Symbol:
CCL2
NCBI Organism:
Homo sapiens
Protein Accession #:
P13500
Protein GI Number:
126842
Purification:
Antibody is purified by protein A affinity chromatography.
Research Area:
Innate Immunity
Swissprot #:
P13500
User NOte:
Optimal dilutions for each application to be determined by the researcher.