LYN Monoclonal Antibody
| Code | Size | Price |
|---|
| PSI-32-189-0.1mL | 0.1mL | £626.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Mouse
Antibody Isotype: IgG2b
Antibody Clonality: Monoclonal
Antibody Clone: 2H8D7
Regulatory Status: RUO
Target Species: Human
Application: Enzyme-Linked Immunosorbent Assay (ELISA)
Storage:
LYN monoclonal antibody can be stored at -20˚C, stable for one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Documents
Further Information
Additional Names:
JTK8, V-yes-1 Yamaguchi sarcoma viral related oncogene homologJTK8, p53Lyn, p56Lyn
Application Note:
ELISA:Propose dilution 1:10,000.
Determining optimal working dilutions by titration test.
Determining optimal working dilutions by titration test.
Background:
Lyn (also known as p53/56 Lyn) is a membrane-associated protein tyrosine kinase (PTK) mostly expressed in hemopoietic cells which is important in cellular signaling. It contains an SH2 and SH3 domain and has been found to be cleaved after activation of caspases in apoptosis. A member of the Src family of PTKs, there are two known isoforms for Lyn which plays an indispensable role in the Fc epsilon RI (Fcer1) and the B-cell IgM receptor signaling pathway and is essential for Syk activation and Lat phosphorylation after Fcer1 aggregation and can also phosphor-ylate Tec on multiple residues. Lyn can also be regulated by IL-2 and IL-3.Lyn is a member of the src family of non-receptor protein tyrosine kinases that is predominantly expressed in haematopoietic tissues. Like all members of the src family, lyn is thought to participate in signal transduction from cell surface receptors that lack intrinsic tyrosine kinase activity. It is associated with a number of cell surface receptors including the B cell antigen receptor and immunoglobulin E receptor (FceRI).
Background References:
- Sakaguchi, A.Y.,et al.Genet. 34: 175.
- Hibbs, M.L.,et al.Biol. 29: 397-400.
- Williams, J.C.,et al.Trends Biochem. Sci. 23: 179-184.
Buffer:
Ascitic fluid containing 0.03% sodium azide.
Concentration:
batch dependent
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Immunogen:
Ni-NTA purified truncated recombinant Lyn expressed in E. Coli strain BL21 (DE3).
NCBI Gene ID #:
4067
NCBI Official Name:
v-yes-1 Yamaguchi sarcoma viral related oncogene homolog
NCBI Official Symbol:
LYN
NCBI Organism:
Homo sapiens
Protein Accession #:
P07948
Protein GI Number:
125480
Research Area:
Signal Transduction
Swissprot #:
P07948
User NOte:
Optimal dilutions for each application to be determined by the researcher.