Desmin Monoclonal Antibody
| Code | Size | Price |
|---|
| PSI-32-145-0.1mg | 0.1mg | £524.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Mouse
Antibody Isotype: IgG1
Antibody Clonality: Monoclonal
Antibody Clone: 10H7D2
Regulatory Status: RUO
Target Species: Human
Applications:
- Enzyme-Linked Immunosorbent Assay (ELISA)
- Immunohistochemistry (IHC)
- Western Blot (WB)
Storage:
Desmin monoclonal antibody can be stored at -20˚C, stable for one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Documents
Further Information
Additional Names:
CSM1, CSM2, LGMD2R
Application Note:
Western Blot:1:1,000 - 1:2,000
IHC(P):1:1,000 - 1:2,000
IHC(F):1:1,000 - 1:2,000
ELISA:Propose dilution 1:10,000.
Determining optimal working dilutions by titration test.
IHC(P):1:1,000 - 1:2,000
IHC(F):1:1,000 - 1:2,000
ELISA:Propose dilution 1:10,000.
Determining optimal working dilutions by titration test.
Background:
Desmin (DES), with 470-amino acid protein (about 52 kDa), belongs to the intermediate filament family and Desmin is class III intermediate filaments found in muscle cells. Homopolymers of Desmin form a stable intracytoplasmic filamentous network connecting myofibrils to each other and to the plasma membrane.Mutations in Desmin are associated with desmin-related myopathy, a familial cardiac and skeletal myopathy (CSM), and with distal myopathies.Desmin is also expressed in smooth muscle cells of both airways and alveolar ducts and Desmin is a load-bearing protein that stiffens the airways and consequently the lung and modulates airway contractile response.
Background References:
- Felix R. Shardonofsky, Yassemi Capetanaki, and Aladin M. Boriek. Am J Physiol Lung Cell Mol Physiol, May 2006; 290: L890 - L896.
- Xupei Huang, Jian Li, Dalton Foster. Experimental Biology and Medicine, Dec 2002; 227: 1039.
Buffer:
Purified antibody in PBS containing 0.03% sodium azide.
Concentration:
batch dependent
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Immunogen:
Ni-NTA purified truncated recombinant Desmin expressed in E. Coli strain BL21 (DE3).
NCBI Gene ID #:
1674
NCBI Official Name:
desmin
NCBI Official Symbol:
DES
NCBI Organism:
Homo sapiens
Protein Accession #:
P17661
Protein GI Number:
6686280
Swissprot #:
P17661
User NOte:
Optimal dilutions for each application to be determined by the researcher.