ASCL1 Antibody
| Code | Size | Price |
|---|
| PSI-27-561-100ul | 100ul | £609.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Rabbit
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Target Species: Human
Applications:
- Enzyme-Linked Immunosorbent Assay (ELISA)
- Immunohistochemistry (IHC)
- Western Blot (WB)
Storage:
For short periods of storage (days) store at 4˚C. For longer periods of storage, store ASCL1 antibody at -20˚C. As with any antibody avoid repeat freeze-thaw cycles.
Documents
Further Information
Additional Names:
ASCL1, ASH1, HASH1, MASH1, bHLHa46
Application Note:
ASCL1 antibody can be used for detection of ASCL1 by ELISA at 1:312500. ASCL1 antibody can be used for detection of ASCL1 by western blot at 1.25 μg/mL, and HRP conjugated secondary antibody should be diluted 1:50,000 - 100,000.
Background:
ASCL1 encodes a member of the basic helix-loop-helix (BHLH) family of transcription factors. The protein activates transcription by binding to the E box (5'-CANNTG-3'). Dimerization with other BHLH proteins is required for efficient DNA binding. This protein plays a role in the neuronal commitment and differentiation and in the generation of olfactory and autonomic neurons. It is highly expressed in medullary thyroid cancer and small cell lung cancer and may be a useful marker for these cancers.
Background References:
- Somasundaram, K., et al., (2005) Oncogene. 24(47), 7073-83.
Buffer:
Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
Concentration:
batch dependent
Conjugate:
Unconjugated
Immunogen:
Antibody produced in rabbits immunized with a synthetic peptide corresponding a region of human ASCL1.
NCBI Gene ID #:
429
NCBI Official Name:
achaete-scute family bHLH transcription factor 1
NCBI Official Symbol:
ASCL1
NCBI Organism:
Homo sapiens
Physical State:
Liquid
PREDICTED MOLECULAR WEIGHT:
25 kDa
Protein Accession #:
NP_004307
Protein GI Number:
55743094
Purification:
Antibody is purified by protein A chromatography method.
Research Area:
Transcription ,Cancer ,Neuroscience
Swissprot #:
P50553
User NOte:
Optimal dilutions for each application to be determined by the researcher.