CIB1 Monoclonal Antibody

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ProSci
Product Code: PSI-32-136
Product Group: Primary Antibodies
Supplier: ProSci
CodeSizePrice
PSI-32-136-0.1mg0.1mg£560.00
Quantity:
Prices exclude any Taxes / VAT

Overview

Host Type: Mouse
Antibody Clonality: Monoclonal
Antibody Clone: 5A1F5E12
Regulatory Status: RUO
Target Species: Human
Applications:
  • Enzyme-Linked Immunosorbent Assay (ELISA)
  • Immunohistochemistry (IHC)
  • Western Blot (WB)
Storage:
CIB1 monoclonal antibody can be stored at -20˚C, stable for one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Images

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Western blot analysis using CIB1 monoclonal antibody against truncated CIB1 recombinant protein and A431 cell lysate.
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Western blot analysis using CIB1 monoclonal antibody against truncated CIB1 recombinant protein and A431 cell lysate.

Documents

Further Information

Additional Names:
CIB, CIBP, KIP1, PRKDCIP, SIP2-28
Application Note:
Western Blot:1:500 - 1:2,000
IHC(P):1:500 - 1:2,000
IHC(F):1:500 - 1:2,000
ELISA:Propose dilution 1:10,000.
Determining optimal working dilutions by titration test.
Background:
CIB1(also designated calcium and integrin binding 1 or calmyrin),with 191-amino acid protein(about 21 kDa), belongs to the calcium-binding protein family.CIB1 is known to interact with DNA-dependent protein kinase and may play a role in kinase-phosphatase regulation of DNA end joining.CIB1 is an EF-hand-containing protein that binds multiple effector proteins, including the platelet alpha(IIb)beta(3) integrin and several serine/threonine kinases and potentially modulates their function.CIB1 regulates platelet aggregation in hemostasis through a specific interaction with the alpha(IIb) cytoplasmic domain of platelet integrin alpha(IIb)beta(3). CIB1 is also ubiquitously expressed activating and inhibiting protein ligand of the InsP3R.
Background References:
  • Holly R. Gentry,Alex U. Singer, Laurie Betts. J. Biol. Chem., Mar 2005; 280: 8407 - 8415.
  • Carl White, Jun Yang, Mervyn J. Monteiro. J. Biol. Chem., Jul 2006; 281: 20825 ? 20833.
Buffer:
Ascitic fluid containing 0.03% sodium azide.
Concentration:
batch dependent
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Immunogen:
Ni-NTA purified truncated recombinant CIB1 expressed in E. Coli strain BL21 (DE3).
NCBI Gene ID #:
10519
NCBI Official Name:
calcium and integrin binding 1 (calmyrin)
NCBI Official Symbol:
CIB1
NCBI Organism:
Homo sapiens
Protein Accession #:
NP_001264693.1
Protein GI Number:
480540325
Research Area:
Signal Transduction
Swissprot #:
Q99828
User NOte:
Optimal dilutions for each application to be determined by the researcher.