HDAC8 Antibody
| Code | Size | Price |
|---|
| PSI-79-160-0.1mg | 0.1mg | £488.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Rabbit
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Target Species:
- Human
- Mouse
- Rat
Applications:
- Immunofluorescence (IF)
- Immunohistochemistry (IHC)
Storage:
Store antibody at -20˚C for up to one year.
Documents
Further Information
Additional Names:
HD8, WTS, RPD3, CDA07, CDLS5, MRXS6, HDACL1, MAPKAPK1A, RSK1, HD8, HDA8
Application Note:
Immunohistochemistry: 1:50~1:100, Immunofluorescence: 1:100~1:200
Background:
Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. The protein encoded by HDAC8 gene belongs to class I of the histone deacetylase family. It catalyzes the deacetylation of lysine residues in the histone N-terminal tails and represses transcription in large multiprotein complexes with transcriptional co-repressors. Multiple transcript variants encoding different isoforms have been found for this gene.
Background References:
- Lee H, et al. (2004) Mol Cell Biol. 24 (2): 765-773.
Buffer:
Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Concentration:
1 mg/mL
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Immunogen:
HDAC8 (Phospho-Ser39) antibody was raised against a peptide sequence around phosphorylation site of serine 39 (R-A-S (p) -M-V) derived from Human HDAC8.
Modifications:
Phospho-Specific
NCBI Gene ID #:
55869
NCBI Official Name:
histone deacetylase 8
NCBI Official Symbol:
HDAC8
NCBI Organism:
Homo sapiens
Physical State:
Liquid
PREDICTED MOLECULAR WEIGHT:
42 kDa
Protein Accession #:
NP_001159890.1
Protein GI Number:
262073088
Purification:
Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy using non-phosphopeptide.
Research Area:
Phospho-Specific,Cell Cycle
SPECIFICITY:
This antibody detects endogenous level of HDAC8 only when phosphorylated at serine 39.
Swissprot #:
Q9BY41