Thyroid Hormone Receptor Monoclonal Antibody
| Code | Size | Price |
|---|
| PSI-50-171-0.1mL | 0.1mL | £686.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Mouse
Antibody Isotype: IgG2A
Antibody Clonality: Monoclonal
Regulatory Status: RUO
Target Species:
- Canine (dog)
- Human
- Mouse
- Rat
Application: Western Blot (WB)
Storage:
Thyroid Hormone Receptor antibody can be stored at -20˚C and is stable at -20˚C for at least 1 year.
Documents
Further Information
Application Note:
The antibody has been directly tested for reactivity in Western blots with human tissue. It is anticipated that the antibody will react with canine, mouse and rat based on the fact that these species have 100% homology with the amino acid sequence used as antigen.
Background:
Thyroid hormones are essential for development of the central nervous system and deficits in these hormones during development affects such cognitive functions as learning and memory (Ambrogini et al., 2005; Chan and Kilby, 2000). Thyroid hormones exert their physiological role mainly through binding to specific nuclear receptors including the predominant isoforms of thyroid hormone receptors TRalpha1, TRalpha2, TRbeta1 and TRbeta2. TRalpha1, TRbeta1 and TRbeta2 bind T3 with high affinity and also bind to thyroid hormone response elements (TREs) on chromatin to regulate the transcriptional processes in several target tissues, including adult rat brain (Constantinou et al., 2005).
Background References:
- Ambrogini P, Cuppini R, Ferri P, Mancini C, Ciaroni S, Voci A, Gerdoni E, Gallo G (2005) Thyroid hormones affect neurogenesis in the dentate gyrus of adult rat. Neuroendocrinology 81:244-253.
- Chan S, Kilby MD (2000) Thyroid hormone and central nervous system development. J Endocrinol 165:1-8.
- Constantinou C, Margarity M, Valcana T (2005) Region-specific effects of hypothyroidism on the relative expression of thyroid hormone receptors in adult rat brain. Mol Cell Biochem 278:93-100.
Concentration:
batch dependent
Conjugate:
Unconjugated
Immunogen:
Peptide corresponding to amino acid residues from the N-terminal region of human thyroid hormone receptor, a1/a2-isotype.
NCBI Gene ID #:
7067
NCBI Official Name:
thyroid hormone receptor, alpha
NCBI Official Symbol:
THRA
NCBI Organism:
Homo sapiens
Physical State:
Liquid
PREDICTED MOLECULAR WEIGHT:
50/58
Protein Accession #:
P10827
Protein GI Number:
135705
Purification:
Protein G purified
Swissprot #:
P10827
User NOte:
Optimal dilutions for each application to be determined by the researcher.