Retinoic Acid Receptor Monoclonal Antibody
| Code | Size | Price |
|---|
| PSI-50-177-0.1mL | 0.1mL | £686.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Mouse
Antibody Isotype: IgG1
Antibody Clonality: Monoclonal
Regulatory Status: RUO
Target Species:
- Canine (dog)
- Cavia (Guinea pig)
- Human
- Mouse
- Rat
Application: Western Blot (WB)
Storage:
Retinoic Acid Receptor antibody can be stored at -20˚C and is stable at -20˚C for at least 1 year.
Documents
Further Information
Application Note:
The antibody has been directly tested for reactivity in Western blots in human tissues. It is anticipated that the antibody will also work with canine, guinea pig, mouse and rat tissues based on the fact that these species have 100% homology with the amino acid sequence used as antigen.
Background:
Retinoic Acid (RA; active metabolite of vitamin A) plays a prominent role in regulating the transition of proliferating precursor cells (such as carcinoma cells and neuronal precursors) to postmitotic differentiated cells (Joshi et al., 2005). The Retinoid X receptors (RXRs) family (RXRalpha, beta and gamma) preferentially bind 9-cis-RA and regulate gene transcription by forming heterodimers with a second family of RA receptors (RARs). RAs have been suggested to potentially play a therapeutic role in cervical cancer (Abu et al., 2005). RAs are known to play key roles in neuronal development and an increasing body of evidence indicates that retinoid signaling may regulate synaptic plasticity and associated learning and memory behaviors (Lane and Bailey, 2005).
Background References:
- Abu J, Batuwangala M, Herbert K, Symonds P (2005) Retinoic acid and retinoid receptors: potential chemopreventive and therapeutic role in cervical cancer. Lancet Oncol 6:712-720.
- Joshi S, Guleria R, Pan J, Dipette D, Singh US (2005) Retinoic acid receptors and tissue-trans-glutaminase mediate short-term effect of retinoic acid on migration and invasion of neuroblastoma SH-SY5Y cells. Oncogene advance online publication 12 September 2005; doi: 10.1038/sj.onc.1209027.
- Lane MA, Bailey SJ (2005) Role of retinoid signalling in the adult brain. Prog Neurobiol 75:275-293.
Concentration:
batch dependent
Conjugate:
Unconjugated
Immunogen:
Peptide corresponding to amino acids from N-terminal region of human retinoic acid receptor, b-isotype.
NCBI Gene ID #:
5915
NCBI Official Name:
retinoic acid receptor, beta
NCBI Official Symbol:
RARB
NCBI Organism:
Homo sapiens
Physical State:
Liquid
PREDICTED MOLECULAR WEIGHT:
48
Protein Accession #:
P10826
Protein GI Number:
17380507
Purification:
Protein G purified
Swissprot #:
P10826
User NOte:
Optimal dilutions for each application to be determined by the researcher.