SORL1 Monoclonal Antibody

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ProSci
Product Code: PSI-32-218
Product Group: Primary Antibodies
Supplier: ProSci
CodeSizePrice
PSI-32-218-0.1mL0.1mL£626.00
Quantity:
Prices exclude any Taxes / VAT

Overview

Host Type: Mouse
Antibody Isotype: IgG1
Antibody Clonality: Monoclonal
Antibody Clone: 7D7B11
Regulatory Status: RUO
Target Species: Human
Applications:
  • Enzyme-Linked Immunosorbent Assay (ELISA)
  • Western Blot (WB)
Storage:
SORL1 monoclonal antibody can be stored at -20˚C, stable for one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

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Western blot analysis using SORL1 monoclonal antibody against truncated SORL1 - MBP recombinant protein and SORL1 (aa2159 - 2214) / hIgGFc transfected CHO - K1 cell lysate.
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Western blot analysis using SORL1 monoclonal antibody against truncated SORL1 - MBP recombinant protein and SORL1 (aa2159 - 2214) / hIgGFc transfected CHO - K1 cell lysate.

Documents

Further Information

Additional Names:
C11orf32, Low-density lipoprotein receptor relative with 11 ligand-binding repeats, LDLR relative with 11 ligand-binding repeats, LR11, LRP9, SORLA, gp250, SorLA-1, C11orf32
Application Note:
Western Blot:1:500 - 1:2,000
ELISA:Propose dilution 1:10,000.
Determining optimal working dilutions by titration test.
Background:
SORL1 (sortilin-related receptor, L A repeats containing) also known as sorting protein-related receptor containing LDLR class A (SorLA), is a Type I membrane protein that may be involved in cell-cell interaction. SorLA, a single transmembrane receptor, binds LDL and transports it into cells by endocytosis. SorLA is synthesized as a proreceptor which is processed to the mature form by a furin-like propeptidase. It can also bind to RAP (receptor-associated protein). SorLA is a multifunctional endocytis receptor important in lipoprotein and protease uptake. The N-terminal propeptide, which is removed, can be cleaved by furin or homologous proteases. Endogenous SorLA binds the neuropeptide head activator (HA) and is important for HA signaling and function. The gene encoding for the protein maps to chromosome 8p23.1. SorLA is expressed mainly in brain (cerebral cortex, cerebellum and the occipital pole), but can also be found in liver, spinal cord, kidney, testis and pancreas.
Background References:
  • Scherzer CR. Offe K. Gearing M. et al. Arch Neurol. 2004, Aug, 61(8):1200-5.
  • Gabrielsson BG. Olofsson LE. Sjogren A. et al. Obes Res. 2005, Apr, 13(4):649-52.
  • Shah S. Yu G. Mol Interv. 2006, Apr, 6(2):74-6, 58. Review.
Buffer:
Ascitic fluid containing 0.03% sodium azide.
Concentration:
batch dependent
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Immunogen:
Purified truncated recombinant SORL1 (aa2159-2214)-MBP fusion protein is expressed in E. Coli strain BL21 (DE3).
NCBI Gene ID #:
6653
NCBI Official Name:
sortilin-related receptor, L(DLR class) A repeats containing
NCBI Official Symbol:
SORL1
NCBI Organism:
Homo sapiens
Protein Accession #:
Q92673
Protein GI Number:
296452912
Research Area:
Neuroscience
Swissprot #:
Q92673
User NOte:
Optimal dilutions for each application to be determined by the researcher.