GNAI1 Antibody

Product Code:

PSI-26-905

Product Group:

Primary Antibodies

Supplier:

ProSci

Host Type:

Rabbit

Antibody Clonality:

Polyclonal

Regulatory Status:

RUO

Target Species:

Fly
Human
Mouse
Rat

Applications:

Enzyme-Linked Immunosorbent Assay (ELISA)
Western Blot (WB)

Storage:

For short periods of storage (days) store at 4˚C. For longer periods of storage, store GNAI1 antibody at -20˚C. As with any antibody avoid repeat freeze-thaw cycles.

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Code	Size	Price

PSI-26-905-100ul

100ul

£662.00

Quantity:

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Further Information

Additional Names:

GNAI1, Gi

Application Note:

GNAI1 antibody can be used for detection of GNAI1 by ELISA at 1:12500. GNAI1 antibody can be used for detection of GNAI1 by western blot at 1 μg/mL, and HRP conjugated secondary antibody should be diluted 1:50,000 - 100,000.

Background:

Guanine nucleotide-binding proteins (G proteins) form a large family of signal-transducing molecules. They are found as heterotrimers made up of alpha, beta, and gamma subunits. Members of the G protein family have been characterized most extensively on the basis of the alpha subunit, which binds guanine nucleotide, is capable of hydrolyzing GTP, and interacts with specific receptor and effector molecules. The G protein family includes Gs and Gi, the stimulatory and inhibitory GTP-binding regulators of adenylate cyclase; Go, a protein abundant in brain (GNAO1); and transducin-1 (GNAT1) and transducin-2 (GNAT2), proteins involved in phototransduction in retinal rods and cones, respectively.Guanine nucleotide-binding proteins (G proteins) form a large family of signal-transducing molecules. They are found as heterotrimers made up of alpha, beta, and gamma subunits. Members of the G protein family have been characterized most extensively on the basis of the alpha subunit, which binds guanine nucleotide, is capable of hydrolyzing GTP, and interacts with specific receptor and effector molecules. The G protein family includes Gs (MIM 139320) and Gi, the stimulatory and inhibitory GTP-binding regulators of adenylate cyclase; Go, a protein abundant in brain (GNAO1; MIM 139311); and transducin-1 (GNAT1; MIM 139330) and transducin-2 (GNAT2; MIM 139340), proteins involved in phototransduction in retinal rods and cones, respectively (Sullivan et al., 1986 [PubMed 3092218]; Bray et al., 1987 [PubMed 3110783]). Suki et al. (1987) [PubMed 2440724] concluded that the human genome contains at least 3 nonallelic genes for alpha-i-type subunits of G protein; see, e.g, GNAI2 (MIM 139360), GNAI3 (MIM 139370), and GNAIH (MIM 139180).[supplied by OMIM]. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.

Background References:

Hurst, J.H., (2008) Cell. Signal. 20 (2), 381-389.

Buffer:

Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.

Concentration:

batch dependent

Conjugate:

Unconjugated

Immunogen:

Antibody produced in rabbits immunized with a synthetic peptide corresponding a region of human GNAI1.

NCBI Gene ID #:

2770

NCBI Official Name:

guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1

NCBI Official Symbol:

GNAI1

NCBI Organism:

Homo sapiens

Physical State:

Liquid

PREDICTED MOLECULAR WEIGHT:

40 kDa

Protein Accession #:

NP_002060

Protein GI Number:

33946324

Purification:

Antibody is purified by peptide affinity chromatography method.

Research Area:

Cancer ,Signal Transduction

Swissprot #:

P63096

User NOte:

Optimal dilutions for each application to be determined by the researcher.

GNAI1 Antibody

Further Information

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