ProSci

HYAL1 Antibody

Product Code:
 
PSI-26-566
Product Group:
 
Primary Antibodies
Supplier:
 
ProSci
Host Type:
 
Rabbit
Antibody Clonality:
 
Polyclonal
Regulatory Status:
 
RUO
Target Species:
  • Human
  • Rat
Applications:
  • Enzyme-Linked Immunosorbent Assay (ELISA)
  • Western Blot (WB)
Storage:
 
For short periods of storage (days) store at 4˚C. For longer periods of storage, store HYAL1 antibody at -20˚C. As with any antibody avoid repeat freeze-thaw cycles.
1 / 5
Antibody used in IHC on Human Liver at 5.0 ug/ml.
2 / 5
3 / 5
Antibody used in IHC on Human Breast.
4 / 5
Antibody used in WB on Hum. Fetal Lung at 1 ug/ml.
5 / 5
Antibody used in WB on Hum. Fetal Brain at 1 ug/ml.
❮❯

Antibody used in IHC on Human Liver at 5.0 ug/ml.
Antibody used in IHC on Human Breast.
Antibody used in WB on Hum. Fetal Lung at 1 ug/ml.
Antibody used in WB on Hum. Fetal Brain at 1 ug/ml.

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PSI-26-566-100ul100ul£662.00
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Further Information

Additional Names:
HYAL1, HYAL-1, LUCA1, MGC45987, NAT6
Application Note:
HYAL1 antibody can be used for detection of HYAL1 by ELISA at 1:62500. HYAL1 antibody can be used for detection of HYAL1 by western blot at 1 μg/mL, and HRP conjugated secondary antibody should be diluted 1:50,000 - 100,000.
Background:
HYAL1 is a lysosomal hyaluronidase. Hyaluronidases intracellularly degrade hyaluronan, one of the major glycosaminoglycans of the extracellular matrix. Hyaluronan is thought to be involved in cell proliferation, migration and differentiation. This enzyme is active at an acidic pH and is the major hyaluronidase in plasma. Mutations in HYAL1 are associated with mucopolysaccharidosis type IX, or hyaluronidase deficiency. HYAL1 is one of several related genes in a region of chromosome 3p21.3 associated with tumor suppression. Multiple transcript variants encoding different isoforms have been found for HYAL1.This gene encodes a lysosomal hyaluronidase. Hyaluronidases intracellularly degrade hyaluronan, one of the major glycosaminoglycans of the extracellular matrix. Hyaluronan is thought to be involved in cell proliferation, migration and differentiation. This enzyme is active at an acidic pH and is the major hyaluronidase in plasma. Mutations in this gene are associated with mucopolysaccharidosis type IX, or hyaluronidase deficiency. The gene is one of several related genes in a region of chromosome 3p21.3 associated with tumor suppression. Multiple transcript variants encoding different isoforms have been found for this gene.
Background References:
  • Poola, I., (2008) Clin. Cancer Res. 14 (4), 1274-1280.
Buffer:
Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
Concentration:
batch dependent
Conjugate:
Unconjugated
Immunogen:
Antibody produced in rabbits immunized with a synthetic peptide corresponding a region of human HYAL1.
NCBI Gene ID #:
3373
NCBI Official Name:
hyaluronoglucosaminidase 1
NCBI Official Symbol:
HYAL1
NCBI Organism:
Homo sapiens
Physical State:
Liquid
PREDICTED MOLECULAR WEIGHT:
45 kDa
Protein Accession #:
NP_695014
Protein GI Number:
24497566
Purification:
Antibody is purified by peptide affinity chromatography method.
Research Area:
Cancer ,Signal Transduction
Swissprot #:
Q12794
User NOte:
Optimal dilutions for each application to be determined by the researcher.