Beta III Tubulin Monoclonal Antibody
| Code | Size | Price |
|---|
| PSI-50-261-0.1mL | 0.1mL | £686.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Mouse
Antibody Isotype: IgG
Antibody Clonality: Monoclonal
Regulatory Status: RUO
Target Species: Mammal
Applications:
- Immunohistochemistry (IHC)
- Western Blot (WB)
Storage:
Beta III Tubulin antibody can be stored at -20˚C and is stable at -20˚C for at least 1 year.
Documents
Further Information
Background:
Tubulin is the major constituent of microtubules, existing as a heterodimer of the alpha and beta subunits. The beta III isoform of tubulin is found almost exclusively in neuronal processes of adult tissues and is therefore an excellent marker for neurons. Neuron specific, posttranslational modifications within the C-terminal domain of beta III tubulin have been shown to be developmentally regulated suggesting that they may serve to modulate the interaction of tubulin with microtubule associated proteins (Lee et al., 1990). Additionally, beta III tubulin has been found to be highly expressed in cancer cells such as small cell lung cancer, large cell neuroendocrine carcinoma and adenocarcinomas and is correlated with an increasing histological degree of malignancy (Katsetos et al., 2003)
Background References:
- Lee MK, Rebhun LI, Frankfurter A (1990) Posttranslational modification of class III beta tubulin. Proc Natl Acad Sci USA 87(18): 7195-7199.
- Katsetos CD, Herman MM, Mork SJ (2003) Class III beta tubulin in human development and cancer. Cell Motil Cytoskeleton 55(2):77-96.
Concentration:
batch dependent
Conjugate:
Unconjugated
Immunogen:
Synthetic peptide corresponding to beta III tubulin.
NCBI Gene ID #:
246118
NCBI Official Name:
tubulin, beta 3 class III
NCBI Official Symbol:
Tubb3
NCBI Organism:
Rattus norvegicus
Physical State:
Liquid
PREDICTED MOLECULAR WEIGHT:
55
Protein Accession #:
Q4QRB4
Protein GI Number:
81918226
Purification:
Protein G purified
Research Area:
Homeostasis
SPECIFICITY:
Specific for the ~55kDa beta III tubulin protein. This clone is similar to the monoclonal antibody Tuj1.
Swissprot #:
Q4QRB4
User NOte:
Optimal dilutions for each application to be determined by the researcher.