CD56 Antibody
| Code | Size | Price |
|---|
| PSI-79-666-0.1mg | 0.1mg | £481.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Rabbit
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Target Species:
- Human
- Mouse
Application: Western Blot (WB)
Storage:
Store antibody at -20˚C for up to one year.
Documents
Further Information
Additional Names:
CD56, NCAM, MSK39, STK14A, NCAM1
Application Note:
Western Blot: 1:500~1:1000
Background:
NCAM (neural cell adhesion molecule, CD56) is an adhesion glycoprotein with five extracellular immunoglobulin-like domains followed by two fibronectin type III repeats. Structural diversity is introduced by alternative splicing resulting in different cytoplasmic domains (1). NCAM mediates neuronal attachment, neurite extension and cell-cell interactions through homo and heterophilic interactions. PSA (polysialic acid) post-translationally modifies NCAM and increases the metastatic potential of small cell lung carcinoma, Wilms+ tumor, neuroblastoma and rhabdomyosarcoma (2). CD56 and CD16 are commonly used to identify NK cells although some cells with the T cell markers CD3 and CD4 also express CD56 (3).
Background References:
- Cunningham, B. A. et al. (1987) Science 236, 799-806. Seidenfaden, R. et al. (2003) Mol. Cell. Biol. 23, 5908-5918. Robertson, M. J. and Ritz, J. (1990) Blood 76, 2421-2438.
Buffer:
Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Concentration:
1 mg/mL
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Immunogen:
CD56 (NCAM) antibody was raised against a peptide sequence around aa.850~854 (Q-T-K-E-N) derived from Human CD56 (NCAM).
NCBI Gene ID #:
4684
NCBI Official Name:
neural cell adhesion molecule 1
NCBI Official Symbol:
NCAM1
NCBI Organism:
Homo sapiens
Physical State:
Liquid
PREDICTED MOLECULAR WEIGHT:
120 - 220 kDa
Protein Accession #:
NP_000606.3
Protein GI Number:
94420689
Purification:
Antibodies were purified by affinity-chromatography using epitope-specific peptide.
Research Area:
Other
SPECIFICITY:
This antibody detects endogenous levels of total NCAM protein.
Swissprot #:
P13591