CDC2 Antibody

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ProSci
Product Code: PSI-79-482
Product Group: Primary Antibodies
Supplier: ProSci
CodeSizePrice
PSI-79-482-0.1mg0.1mg£488.00
Quantity:
Prices exclude any Taxes / VAT

Overview

Host Type: Rabbit
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Target Species:
  • Human
  • Mouse
  • Rat
Application: Western Blot (WB)
Storage:
Store antibody at -20˚C for up to one year.

Images

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Western blot analysis of lysed extracts from HeLa cells untreated (Lane 1) or treated with UV (lane 2) using CDC2 (Phospho-Tyr15).
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Western blot analysis of lysed extracts from HeLa cells untreated (Lane 1) or treated with UV (lane 2) using CDC2 (Phospho-Tyr15).

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Further Information

Additional Names:
CDC2, CDC28A, P34CDC2, CSBP, CSBP1, CSBP2, CSPB1, MXI2, SAPK2A, CDC28, CDC2A, CDK1, Cyclin-dependent kinase 1
Application Note:
Western Blot: 1:500~1:1000
Background:
Plays a key role in the control of the eukaryotic cell cycle. It is required in higher cells for entry into S-phase and mitosis. p34 is a component of the kinase complex that phosphorylates the repetitive C-terminus of RNA polymerase II.
Background References:
  • Y Gu, et al. (1992) EMBO J. 11 (11): 3995?4005. P Jin, et al. (1996) Cell Biology, Vol 134: 963-970, Tyagi, et al. (2005) Alpna1Carcinogenesis, Volume 26: 1978-1987 (10) Xiang S. et al. (1997) The EMBO Journal 16: 182?192
Buffer:
Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Concentration:
1 mg/mL
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Immunogen:
CDC2 (Phospho-Tyr15) antibody was raised against a peptide sequence around phosphorylation site of tyrosine 15 (G-T-Y (p) -G-V) derived from Human CDC2.
Modifications:
Phospho-Specific
NCBI Gene ID #:
983
NCBI Official Name:
cyclin-dependent kinase 1
NCBI Official Symbol:
CDK1
NCBI Organism:
Homo sapiens
Physical State:
Liquid
PREDICTED MOLECULAR WEIGHT:
34 kDa
Protein Accession #:
NP_001163877.1
Protein GI Number:
281427278
Purification:
Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy using non-phosphopeptide.
Research Area:
Phospho-Specific,Apoptosis,Cancer,Cell Cycle
SPECIFICITY:
This antibody detects endogenous level of CDC2 only when phosphorylated at tyrosine 15.
Swissprot #:
P06493