c-Kit Antibody

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ProSci
Product Code: PSI-79-480
Product Group: Primary Antibodies
Supplier: ProSci
CodeSizePrice
PSI-79-480-0.1mg0.1mg£488.00
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Overview

Host Type: Rabbit
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Target Species:
  • Human
  • Mouse
  • Rat
Application: Western Blot (WB)
Storage:
Store antibody at -20˚C for up to one year.

Images

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Western blot analysis of lysed extracts from HeLa cells untreated or treated with IFN-α using c-Kit (Phospho-Tyr721).
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Western blot analysis of lysed extracts from HeLa cells untreated or treated with IFN-α using c-Kit (Phospho-Tyr721).

Documents

Further Information

Additional Names:
PBT, SCFR, C-Kit, CD117, CTNNG, DP3,
Application Note:
Western Blot: 1:500~1:1000
Background:
This is the receptor for stem cell factor (mast cell growth factor). It has a tyrosine-protein kinase activity. Binding of the ligands leads to the autophosphorylation of KIT and its association with substrates such as phosphatidylinositol 3-kinase (Pi3K)
Background References:
  • Nocka, K. et al. (1990) EMBO J. 9, 1805-1813. Hirota, S. et al. (1998) Science 279, 577-580. Blume-Jensen, P. et al. (2000) Nat. Genet. 24, 157-162. Sattler, M. et al. (1997) J. Biol. Chem. 272, 10248-10253. Gommerman, J. L. et al. (1997) J. Biol. Chem. 272, 30519-30525.
Buffer:
Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Concentration:
1 mg/mL
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Immunogen:
c-Kit (Phospho-Tyr721) antibody was raised against a peptide sequence around phosphorylation site of tyrosine 721 (N-E-Y (p) -M-D) derived from Human c-Kit.
Modifications:
Phospho-Specific
NCBI Gene ID #:
3815
NCBI Official Name:
v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog
NCBI Official Symbol:
KIT
NCBI Organism:
Homo sapiens
Physical State:
Liquid
PREDICTED MOLECULAR WEIGHT:
145 kDa
Protein Accession #:
NP_000213.1
Protein GI Number:
4557695
Purification:
Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy using non-phosphopeptide.
Research Area:
Phospho-Specific
SPECIFICITY:
This antibody detects endogenous level of c-Kit only when phosphorylated at tyrosine 721.
Swissprot #:
P10721