DNA PKcs Antibody
| Code | Size | Price |
|---|
| PSI-79-568-0.1mg | 0.1mg | £481.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Rabbit
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Target Species: Human
Application: Western Blot (WB)
Storage:
Store antibody at -20˚C for up to one year.
Documents
Further Information
Additional Names:
HYRC, p350, DNAPK, DNPK1, HYRC1, XRCC7, DNA-PKcs, EPLG5, HTKL, LERK5, PRKD, PRKDC, P460
Application Note:
Western Blot: 1:500~1:1000
Background:
The PRKDC gene encodes the catalytic subunit of a nuclear DNA-dependent serine/threonine protein kinase (DNA-PK). The second component is the autoimmune antigen Ku (MIM 152690), which is encoded by the G22P1 gene on chromosome 22q. On its own, the catalytic subunit of DNA-PK is inactive and relies on the G22P1 component to direct it to the DNA and trigger its kinase activity; PRKDC must be bound to DNA to express its catalytic properties
Background References:
- Chan DW, et al. (2002) Genes Dev. Sep 15; 16 (18): 2333-2338Ding Q, et al. (2003) Mol Cell Biol. Aug; 23 (16): 5836-5848Douglas P, et al. (2002) Biochem J. Nov 15; 368 (Pt 1): 243-251
Buffer:
Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Concentration:
1 mg/mL
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Immunogen:
DNA PKcs (Ab-2609) antibody was raised against a peptide sequence around aa.2607~2611 (V-E-T-Q-A) derived from Human DNA-PK.
NCBI Gene ID #:
5591
NCBI Official Name:
protein kinase, DNA-activated, catalytic polypeptide
NCBI Official Symbol:
PRKDC
NCBI Organism:
Homo sapiens
Physical State:
Liquid
PREDICTED MOLECULAR WEIGHT:
450 kDa
Protein Accession #:
NP_001075109.1
Protein GI Number:
126032350
Purification:
Antibodies were purified by affinity-chromatography using epitope-specific peptide.
Research Area:
Cell Cycle
SPECIFICITY:
This antibody detects endogenous level of total DNA PKcs protein.
Swissprot #:
P78527