Fas Antibody
| Code | Size | Price |
|---|
| PSI-79-640-0.1mg | 0.1mg | £481.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Rabbit
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Target Species: Human
Application: Western Blot (WB)
Storage:
Store antibody at -20˚C for up to one year.
Documents
Further Information
Additional Names:
APT1, CD95, FAS1, APO-1, FASTM, ALPS1A, TNFRSF6, RP11-399O19.9, IKBE, FASLG receptor, Apoptosis-mediating surface antigen FAS, Apo-1 antigen
Application Note:
Western Blot: 1:1000
Background:
Receptor for TNFSF6/FASLG. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. FAS-mediated apoptosis may have a role in the induction of peripheral tolerance, in the antigen-stimulated suicide of mature T-cells, or both. The secreted isoforms 2 to 6 block apoptosis (in vitro).
Background References:
- Hahne, M. et al. (1995) Int Immunol 7, 1381-6. Nagata, S. (1997) Cell 88, 355-65. Green, D. R. and Ferguson, T. A. (2001) Nat Rev Mol Cell Biol 2, 917-24.
Buffer:
Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Concentration:
1 mg/mL
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Immunogen:
Fas antibody was raised against a peptide sequence around aa.323~327 (E-N-S-N-F) derived from human Fas .
NCBI Gene ID #:
355
NCBI Official Name:
Fas cell surface death receptor
NCBI Official Symbol:
FAS
NCBI Organism:
Homo sapiens
Physical State:
Liquid
PREDICTED MOLECULAR WEIGHT:
40 - 50 kDa
Protein Accession #:
NP_000034.1
Protein GI Number:
4507583
Purification:
Antibodies were purified by affinity-chromatography using epitope-specific peptide.
Research Area:
Apoptosis,Cancer
SPECIFICITY:
This antibody detects endogenous level of total Fas protein.
Swissprot #:
P25445