FoxA2 Antibody
| Code | Size | Price |
|---|
| PSI-79-710-0.1mg | 0.1mg | £481.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Rabbit
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Target Species: Human
Application: Western Blot (WB)
Storage:
Store antibody at -20˚C for up to one year.
Documents
Further Information
Additional Names:
HNF3B, TCF3B, NMDAR1, HNF3B
Application Note:
Western Blot: 1:500~1:1000
Background:
Transcription factor that is involved in embryonic development, establishment of tissue-specific gene expression and regulation of gene expression in differentiated tissues. Is thought to act as a 'pioneer' factor opening the compacted chromatin for other proteins through interactions with nucleosomal core histones and thereby replacing linker histones at target enhancer and/or promoter sites. Binds DNA with the consensus sequence 5'-[AC]A[AT]T[AG]TT[GT][AG][CT]T[CT]-3' . In embryonic development is required for notochord formation. Involved in the development of multiple endoderm-derived organ systems such as the liver, pancreas and lungs; FOXA1 and FOXA2 seem to have at least in part redundant roles. Originally discribed as a transcription activator for a number of liver genes such as AFP, albumin, tyrosine aminotransferase, PEPCK, etc. Interacts with the cis-acting regulatory regions of these genes. Involved in glucose homeostasis; regulates the expression of genes important for glucose sensing in pancreatic beta-cells and glucose homeostasis. Involved in regulation of fat metabolism. Binds to fibrinogen beta promoter and is involved in IL6-induced fibrinogen beta transcriptional activation.
Background References:
- Wolfrum C., Besser D., Luca E., Stoffel M. Proc. Natl. Acad. Sci. U. S. A100:11624-11629 (2003) Motallebipour M., Ameur A., Reddy Bysani M. S., Patra K., Wallerman O., Mangion J., Barker M. A., McKerman K. J., Komorowski J., Wadelius C. Genome Biol. 10:R129. 0-R129. 0 (2009)
Buffer:
Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Concentration:
1 mg/mL
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Immunogen:
FoxA2 (HNF3beta) antibody was raised against a peptide sequence around aa.435~439 ( A-S-P-L-A) derived from Human FoxA2 (HNF3β).
NCBI Gene ID #:
3170
NCBI Official Name:
forkhead box A2
NCBI Official Symbol:
FOXA2
NCBI Organism:
Homo sapiens
Physical State:
Liquid
PREDICTED MOLECULAR WEIGHT:
50 kDa
Protein Accession #:
NP_068556.2
Protein GI Number:
194394143
Purification:
Antibodies were purified by affinity-chromatography using epitope-specific peptide.
Research Area:
Stem Cell
SPECIFICITY:
This antibody detects endogenous level of total FoxA2 protein.
Swissprot #:
Q9Y261