GRASP Antibody
| Code | Size | Price |
|---|
| PSI-79-659-0.1mg | 0.1mg | £481.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Rabbit
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Target Species:
- Human
- Mouse
- Rat
Application: Western Blot (WB)
Storage:
Store antibody at -20˚C for up to one year.
Documents
Further Information
Additional Names:
GRASP-1, Gripap, Grasp, GRIP1-associated protein
Application Note:
Western Blot: 1:500~1:1000
Background:
GRASP (GRP1-associated scaffold protein, tamalin) is a 395 amino acid proteinencoded by the human gene GRASP . GRASP is a scaffold protein that com-prises multiple protein-interacting domains, including a 95 kDa postsynapticdensity protein (PSD-95)/discs-large/ZO-1 (PDZ) domain, a leucine-zipperregion and a carboxyl-terminal PDZ-binding motif. GRASP is involved withintracellular trafficking and contributes to the macromolecular organizationof group 1 metabotropic glutamate receptors (mGluRs) at synapses. GRASPforms a heteromer composed of GRASP , PSCD2 and at least one mGluR-1. Italso interacts with PSCD3, mGluR-2, mGluR-3 and mGluR-5. GRASP is highlyexpressed in brain and has lower levels of expression in lung, heart, embryo, kidney and ovary.
Background References:
- Kitano, J., Kimura, K., Yamazaki, Y., Soda, T., Shigemoto, R., Nakajima, Y. and Nakanishi, S. 2002. Tamalin, J. Neurosci. 22:1280-1289. Hall, B. S., Gabernet-Castello, C., Voak, A., Goulding, D., Natesan, S. K. and Field, M. C. 2006. J. Biol. Chem. 281: 27600-27612. Sugi, T., Oyama, T., Muto, T., Nakanishi, S., Morikawa, K. and Jingami, H. 2007. Crystal structures of autoinhibitory PDZ domain of Tamalin EMBO J. 26: 2192-2205.
Buffer:
Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Concentration:
1 mg/mL
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Immunogen:
GRASP antibody was raised against a peptide sequence around aa. 814-818 (Q-E-I-V-R ) derived from Rat GRASP.
NCBI Gene ID #:
56850
NCBI Official Name:
GRIP1 associated protein 1
NCBI Official Symbol:
GRIPAP1
NCBI Organism:
This antibody was raised against a peptide sequence around aa. 814-818 (Q-E-I-V-R ) derived from Rat GRASP
Physical State:
Liquid
PREDICTED MOLECULAR WEIGHT:
95 kDa
Protein Accession #:
NP_064522.3
Protein GI Number:
46592991
Purification:
Antibodies were purified by affinity-chromatography using epitope-specific peptide
Research Area:
Stem Cell
SPECIFICITY:
This antibody detects endogenous level of total GRASP protein.
Swissprot #:
Q9JHZ4