hnRNP A1 Antibody
| Code | Size | Price |
|---|
| PSI-79-695-0.1mg | 0.1mg | £481.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Rabbit
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Target Species:
- Human
- Mouse
- Rat
Application: Western Blot (WB)
Storage:
Store antibody at -20˚C for up to one year.
Documents
Further Information
Additional Names:
ALS19, ALS20, HNRPA1, IBMPFD3, HNRPA1L3, hnRNPA1, hnRNP-A1, hnRNP A1, MGC102835
Application Note:
Western Blot: 1:500~1:1000
Background:
Heterogeneous nuclear ribonucleoprotein A1 (hnRNP A1) is a member of the hnRNP A/B family of related RNA binding proteins that bind pre-mRNA and are involved in the processing, metabolism and transport of nuclear pre-mRNA transcripts . hnRNP A1 regulates the alternative splicing of c-Src, c-H-Ras and modifies initiation of translation of the fibroblast growth factor 2 mRNA. hnRNP A1 expression level is elevated in many cancers; knockdown of hnRNP A1 leads to apoptosis in various cancer cells . Although predominantly nuclear, hnRNP A1 is continually transported from the nucleus to the cytoplasm where it disassociates from mRNA and is rapidly re-imported into the nucleus . hnRNP A1 binds to cis-acting repressive sequences (CRS) of HIV-1 to influence HIV-1 production . HIV-1 enhances hnRNP A1 expression and promotes the relocalization of hnRNP A1 to the cytoplasm ,
Background References:
- Myer, V. E. and Steitz, J. A. (1995) RNA 1, 171-82. Rooke, N. et al. (2003) Mol Cell Biol 23, 1874-84. Guil, S. et al. (2003) Mol Cell Biol 23, 2927-41. Bonnal, S. et al. (2005) J Biol Chem 280, 4144-53. Patry, C. et al. (2003) Cancer Res 63, 7679-88. Pinol-Roma, S. and Dreyfuss, G. (1992) Nature 355, 730-2. Siomi, M. C. et al. (1997) J Cell Biol 138, 1181-92. Black, A. C. et al. (1996) Virus Genes 12, 275-85. Hadian, K. et al. (2009) J Biol Chem 284, 33384-91. Monette, A. et al. (2009) J Biol Chem 284, 31350-62.
Buffer:
Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Concentration:
1 mg/mL
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Immunogen:
hnRNP A1 (Ab-192) antibody was raised against a peptide sequence around aa.190~194 (S-S-S-Q-R) derived from Human hnRNP A1.
NCBI Gene ID #:
3178
NCBI Official Name:
heterogeneous nuclear ribonucleoprotein A1
NCBI Official Symbol:
HNRNPA1
NCBI Organism:
Homo sapiens
Physical State:
Liquid
PREDICTED MOLECULAR WEIGHT:
34, 39 kDa
Protein Accession #:
NP_002127.1
Protein GI Number:
4504445
Purification:
Antibodies were purified by affinity-chromatography using epitope-specific peptide.
Research Area:
Other
SPECIFICITY:
This antibody detects endogenous levels of total hnRNP A1 protein.
Swissprot #:
P09651