IGF-1R Antibody

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ProSci
Product Code: PSI-79-445
Product Group: Primary Antibodies
Supplier: ProSci
CodeSizePrice
PSI-79-445-0.1mg0.1mg£488.00
Quantity:
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Overview

Host Type: Rabbit
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Target Species:
  • Human
  • Mouse
  • Rat
Applications:
  • Immunofluorescence (IF)
  • Western Blot (WB)
Storage:
Store antibody at -20˚C for up to one year.

Images

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Western blot analysis of lysed extracts from 293 cells untreated or treated with insulin using IGF-1R (Phospho-Tyr1165/Tyr1166).
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Immunofluorescence staining of methanol-fixed MCF cells using IGF-1R (Phospho-Tyr1165/Tyr1166).
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Western blot analysis of lysed extracts from 293 cells untreated or treated with insulin using IGF-1R (Phospho-Tyr1165/Tyr1166).
Immunofluorescence staining of methanol-fixed MCF cells using IGF-1R (Phospho-Tyr1165/Tyr1166).

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Further Information

Additional Names:
IGFR, CD221, IGFIR, JTK13, RAB5, Insulin-like growth factor I receptor, IGF1R, kinase IGF1R
Application Note:
Western Blot: 1:500~1:1000, Immunofluorescence: 1:100~1:200
Background:
This receptor binds insulin-like growth factor 1 (IGF1) with a high affinity and IGF2 with a lower affinity. It has a tyrosine-protein kinase activity, which is necessary for the activation of the IGF1-stimulated downstream signaling cascade. When present in a hybrid receptor with INSR, binds IGF1.
Background References:
  • Li S, et al. (1994) J Biol Chem; 269 (51): 32558-64.
Buffer:
Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Concentration:
1 mg/mL
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Immunogen:
IGF-1R (Phospho-Tyr1165/Tyr1166) antibody was raised against a peptide sequence around phosphorylation site of tyrosine 1165/tyrosine 1166 (T-D-Y (p) -Y (p) -R-K) derived from Human IGF-1R .
Modifications:
Phospho-Specific
NCBI Gene ID #:
3480
NCBI Official Name:
insulin-like growth factor 1 receptor
NCBI Official Symbol:
IGF1R
NCBI Organism:
Homo sapiens
Physical State:
Liquid
PREDICTED MOLECULAR WEIGHT:
200, 95 kDa
Protein Accession #:
NP_000866.1
Protein GI Number:
4557665
Purification:
Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy using non-phosphopeptide.
Research Area:
Phospho-Specific
SPECIFICITY:
This antibody detects endogenous level of IGF-1R onlywhen phosphorylated at tyrosine 1165/tyrosine1166.
Swissprot #:
P08069