IRS-1 Antibody

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ProSci
Product Code: PSI-79-458
Product Group: Primary Antibodies
Supplier: ProSci
CodeSizePrice
PSI-79-458-0.1mg0.1mg£488.00
Quantity:
Prices exclude any Taxes / VAT

Overview

Host Type: Rabbit
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Target Species:
  • Human
  • Mouse
  • Rat
Application: Western Blot (WB)
Storage:
Store antibody at -20˚C for up to one year.

Images

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Western blot analysis of extract from 293 cells untreated or treated with insulin using IRS-1 (Phospho-Ser312).
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Western blot analysis of extract from 293 cells untreated or treated with insulin using IRS-1 (Phospho-Ser312).

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Further Information

Additional Names:
HIRS-1, OCT1, OTF1, HIRS-1, IRS1, Insulin receptor substrate 1
Application Note:
Western Blot: 1:500~1:1000
Background:
May mediate the control of various cellular processes by insulin. When phosphorylated by the insulin receptor binds specifically to various cellular proteins containing SH2 domains such as phosphatidylinositol 3-kinase p85 subunit or GRB2. Activates phosphatidylinositol 3-kinase when bound to the regulatory p85 subunit
Background References:
  • Tzatsos A, et al. (2006) Mol Cell Biol; 26 (1): 63-76Ozes ON, et al. (2001) Proc Natl Acad Sci U S A; 98 (8): 4640-4645Szanto I, et al. (2000) Proc Natl Acad Sci U S A; 97 (5): 2355-2360Ozes ON, et al. (2001) Proc Natl Acad Sci U S A; 98 (8): 4640-4645
Buffer:
Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Concentration:
1 mg/mL
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Immunogen:
IRS-1 (Phospho-Ser312) antibody was raised against a peptide sequence around phosphorylation site of serine 312 (A-T-S (p) -P-A) derived from Human IRS-1.
Modifications:
Phospho-Specific
NCBI Gene ID #:
3667
NCBI Official Name:
insulin receptor substrate 1
NCBI Official Symbol:
IRS1
NCBI Organism:
Homo sapiens
Physical State:
Liquid
PREDICTED MOLECULAR WEIGHT:
180 kDa
Protein Accession #:
NP_005535.1?
Protein GI Number:
5031805
Purification:
Antibodies were purified by affinity-chromatography using epitope-specific peptide.
Research Area:
Phospho-Specific
SPECIFICITY:
This antibody detects endogenous levels of IRS-1 only when phosphorylated at serine 312.
Swissprot #:
P35568