MSK1 Antibody
| Code | Size | Price |
|---|
| PSI-79-578-0.1mg | 0.1mg | £481.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Rabbit
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Target Species:
- Human
- Mouse
- Rat
Application: Western Blot (WB)
Storage:
Store antibody at -20˚C for up to one year.
Documents
Further Information
Additional Names:
MSK1, RLPK, MSPK1, RPS6KA5
Application Note:
Western Blot: 1:500~1:1000
Background:
Serine/threonine kinase required for the mitogen or stress-induced phosphorylation of the transcription factors CREB (cAMP response element-binding protein) and ATF1 (activating transcription factor-1). Essential role in the control of RELA transcriptional activity in response to TNF. Directly represses transcription via phosphorylation of 'Ser-1' of histone H2A. Phosphorylates 'Ser-10' of histone H3 in response to mitogenics, stress stimuli and epidemal growth-factor (EGF), which results in the transcriptional activation of several immediate early genes, including proto-oncogenes c-fos/FOS and c-jun/JUN. May also phosphorylate 'Ser-28' of histone H3. Mediates the mitogen- and stress-induced phosphorylation of high mobility group protein 14 (HMG-14).
Background References:
- Roux PP, et al. (2004) Microbiol Mol Biol Rev. Jun; 68 (2): 320-344McCOY C, et al. (2005) Biochem J. Apr 15; 387 (Pt 2): 507-517
Buffer:
Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Concentration:
1 mg/mL
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Immunogen:
MSK1 (Ab-376) antibody was raised against a peptide sequence around aa.374~378 (G-Y-S-F-V) derived from Human MSK1.
NCBI Gene ID #:
9252
NCBI Official Name:
ribosomal protein S6 kinase, 90kDa, polypeptide 5
NCBI Official Symbol:
RPS6KA5
NCBI Organism:
Homo sapiens
Physical State:
Liquid
PREDICTED MOLECULAR WEIGHT:
90 kDa
Protein Accession #:
NP_004746.2
Protein GI Number:
32528295
Purification:
Antibodies were purified by affinity-chromatography using epitope-specific peptide.
Research Area:
Other
SPECIFICITY:
This antibody detects endogenous level of total MSK1 protein.
Swissprot #:
O75582