PDGF Receptor beta Antibody
| Code | Size | Price |
|---|
| PSI-79-586-0.1mg | 0.1mg | £481.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Rabbit
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Target Species:
- Human
- Mouse
- Rat
Application: Western Blot (WB)
Storage:
Store antibody at -20˚C for up to one year.
Documents
Further Information
Additional Names:
IMF1, IBGC4, JTK12, PDGFR, CD140B, PDGFR1, PDGFR-1,
Application Note:
Western Blot: 1:500~1:1000
Background:
PDGF Receptor β encodes a cell surface tyrosine kinase receptor for members of the platelet-derived growth factor family. These growth factors are mitogens for cells of mesenchymal origin. The identity of the growth factor bound to a receptor monomer determines whether the functional receptor is a homodimer or a heterodimer, composed of both platelet-derived growth factor receptor alpha and beta polypeptides. This gene is flanked on chromosome 5 by the genes for granulocyte-macrophage colony-stimulating factor and macrophage-colony stimulating factor receptor; all three genes may be implicated in the 5-q syndrome. A translocation between chromosomes 5 and 12, that fuses this gene to that of the translocation, ETV6, leukemia gene, results in chronic myeloproliferative disorder with eosinophilia.
Background References:
- Lederle W, et al. (2006) Am J Pathol ; 169 (5): 1767-1783. Vignais ML, et al. (1999) Mol Cell Biol; 19 (5): 3727-3735. Herrlich A, et al. (1998) Proc Natl Acad Sci U S A; 95 (15): 8985-8990. Heuchel R, et al. (1999) Proc Natl Acad Sci U S A; 96 (20): 11410-11415.
Buffer:
Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Concentration:
1 mg/mL
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Immunogen:
PDGF Receptor beta (Ab-751) antibody was raised against a peptide sequence around aa.749~753 (V-D-Y-V-P) derived from Human PDGFRb.
NCBI Gene ID #:
5159
NCBI Official Name:
platelet-derived growth factor receptor, beta polypeptide
NCBI Official Symbol:
PDGFRB
NCBI Organism:
Homo sapiens
Physical State:
Liquid
PREDICTED MOLECULAR WEIGHT:
190 kDa
Protein Accession #:
NP_002600.1
Protein GI Number:
4505683
Purification:
Antibodies were purified by affinity-chromatography using epitope-specific peptide.
Research Area:
Other
SPECIFICITY:
This antibody detects endogenous level of total PDGF Receptor β protein.
Swissprot #:
P09619