PKR Antibody

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ProSci
Product Code: PSI-79-399
Product Group: Primary Antibodies
Supplier: ProSci
CodeSizePrice
PSI-79-399-0.1mg0.1mg£481.00
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Overview

Host Type: Rabbit
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Target Species: Human
Applications:
  • Immunofluorescence (IF)
  • Immunohistochemistry (IHC)
Storage:
Store antibody at -20˚C for up to one year.

Images

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Immunohistochemical analysis of paraffin-embedded human colon carcinoma tissue using PKR (Ab-451).
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Immunofluorescence staining of methanol-fixed HeLa cells using PKR (Ab-451).
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Immunohistochemical analysis of paraffin-embedded human colon carcinoma tissue using PKR (Ab-451).
Immunofluorescence staining of methanol-fixed HeLa cells using PKR (Ab-451).

Documents

Further Information

Additional Names:
PKR, PRKR, EIF2AK1, CBL2, RNF55, ADRB2, E2AK2, EIF2AK2, EIF2aK
Application Note:
Immunohistochemistry: 1:50~1:100, Immunofluorescence: 1:100~1:200
Background:
Following activation by double-stranded RNA in the presence of ATP, the kinase becomes autophosphorylated and can catalyze the phosphorylation of the translation initiation factor EIF2S1, which leads to an inhibition of the initiation of protein synthesis. Double-stranded RNA is generated during the course of a viral infection.
Background References:
  • Ingrid K. Ruf, et, al. (2005) J. Virol ; 79: 14562 - 14569. Christy M. Hebner, et, al. (2006) J. Gen. Virol ; 87: 3183 - 3193. Rika van Huizen, et, al. (2003) J. Biol. Chem ; 278: 15558 - 15564.
Buffer:
Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Concentration:
1 mg/mL
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Immunogen:
PKR (Ab-451) antibody was raised against a peptide sequence around aa.449~453 (K-G-T-L-R) derived from Human PKR.
NCBI Gene ID #:
5610
NCBI Official Name:
eukaryotic translation initiation factor 2-alpha kinase 2
NCBI Official Symbol:
EIF2AK2
NCBI Organism:
Homo sapiens
Physical State:
Liquid
PREDICTED MOLECULAR WEIGHT:
68 kDa
Protein Accession #:
NP_001129123.1
Protein GI Number:
208431827
Purification:
Antibodies were purified by affinity-chromatography using epitope-specific peptide.
Research Area:
Other
SPECIFICITY:
This antibody detects endogenous level of total PKR protein.
Swissprot #:
P19525