SHP-2 Antibody

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ProSci
Product Code: PSI-79-414
Product Group: Primary Antibodies
Supplier: ProSci
CodeSizePrice
PSI-79-414-0.1mg0.1mg£481.00
Quantity:
Prices exclude any Taxes / VAT

Overview

Host Type: Rabbit
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Target Species:
  • Human
  • Mouse
  • Rat
Applications:
  • Immunofluorescence (IF)
  • Immunohistochemistry (IHC)
  • Western Blot (WB)
Storage:
Store antibody at -20˚C for up to one year.

Images

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Western blot analysis of lysed extracts from 3T3 cells using SHP-2 (Ab-542).
2 / 2
<b>Top Image:</b> Immunohistochemical analysis of paraffin-embedded human breast carcinoma tissue using SHP-2 (Ab-542).<b>Bottom Image:</b> Immunofluorescence staining of methanol-fixed HeLa cells using SHP-2 (Ab-542).
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Western blot analysis of lysed extracts from 3T3 cells using SHP-2 (Ab-542).
<b>Top Image:</b> Immunohistochemical analysis of paraffin-embedded human breast carcinoma tissue using SHP-2 (Ab-542).<b>Bottom Image:</b> Immunofluorescence staining of methanol-fixed HeLa cells using SHP-2 (Ab-542).

Documents

Further Information

Additional Names:
CFC, NS1, SHP2, BPTP3, PTP2C, PTP-1D, SH-PTP2, SH-PTP3, ERBB, ERBB1, HER1, Protein-tyrosine phosphatase 2C
Application Note:
Western Blot: 1:500~1:1000, Immunohistochemistry: 1:50~1:100, Immunofluorescence: 1:100~1:200
Background:
Acts downstream of various receptor and cytoplasmic protein tyrosine kinases to participate in the signal transduction from the cell surface to the nucleus.
Background References:
  • Ferjoux G, et al. (2003) Mol Biol Cell. 2003; 14 (9): 3911-3928. Shi ZQ, et al. (2000) Mol Cell Biol ; 20 (5): 1526-1536. Li C, Friedman JM. (1999) Proc Natl Acad Sci U S A ; 96 (17): 9677-9682Manes S, et al. (1999) Mol Cell Biol ; 19 (4): 3125-3135. Oh ES, et al. (1999) Mol Cell Biol; 19 (4): 3205-3215.
Buffer:
Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Concentration:
1 mg/mL
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Immunogen:
SHP-2 (Ab-542) antibody was raised against a peptide sequence around aa. 540~544 (H-E-Y-T-N) derived from Human SHP-2.
NCBI Gene ID #:
5781
NCBI Official Name:
protein tyrosine phosphatase, non-receptor type 11
NCBI Official Symbol:
PTPN11
NCBI Organism:
Homo sapiens
Physical State:
Liquid
PREDICTED MOLECULAR WEIGHT:
72 kDa
Protein Accession #:
NP_002825.3
Protein GI Number:
33356177
Purification:
Antibodies were purified by affinity-chromatography using epitope-specific peptide.
Research Area:
Other
SPECIFICITY:
This antibody detects endogenous level of total SHP-2 protein.
Swissprot #:
Q06124