SP1 Antibody
| Code | Size | Price |
|---|
| PSI-79-481-0.1mg | 0.1mg | £488.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Rabbit
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Target Species:
- Human
- Rat
Application: Western Blot (WB)
Storage:
Store antibody at -20˚C for up to one year.
Documents
Further Information
Additional Names:
TSFP1, TSFP1, Sp1 transcription factor
Application Note:
Western Blot: 1:500~1:1000
Background:
Transcription factor that can activate or repress transcription in response to physiological and pathological stimuli. Binds with high affinity to GC-rich motifs and regulates the expression of a large number of genes involved in a variety of processes such as cell growth, apoptosis, differentiation and immune responses. Highly regulated by post-translational modifications (phosphorylations, sumoylation, proteolytic cleavage, glycosylation and acetylation). Binds also the PDGFR-alpha G-box promoter. May have a role in modulating the cellular response to DNA damage. Implicated in chromatin remodeling. Plays a role in the recruitment of SMARCA4/BRG1 on the c-FOS promoter. Plays an essential role in the regulation of FE65 gene expression.
Background References:
- Thiesen HJ, et al. (1990) Nucleic Acids Res. 18 (11): 3203-9. Zutter MM, et al. (1997) Blood. 90 (2): 678-89. Lou Z, et al. (2005) Cancer Res. 65 (3): 1007-17
Buffer:
Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Concentration:
1 mg/mL
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Immunogen:
SP1 (Phospho-Thr739) antibody was raised against a peptide sequence around phosphorylation site of threonine 739 (T-A-T (p) -P-S) derived from human SP1 .
Modifications:
Phospho-Specific
NCBI Gene ID #:
6667
NCBI Official Name:
Sp1 transcription factor
NCBI Official Symbol:
SP1
NCBI Organism:
Homo sapiens
Physical State:
Liquid
PREDICTED MOLECULAR WEIGHT:
90 kDa
Protein Accession #:
NP_612482.2
Protein GI Number:
38372901
Purification:
Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy using non-phosphopeptide.
Research Area:
Phospho-Specific
SPECIFICITY:
This antibody detects endogenous levels of SP1 only when phosphorylated at threonine 739.
Swissprot #:
P08047