STAT2 Antibody
| Code | Size | Price |
|---|
| PSI-79-429-0.1mg | 0.1mg | £481.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Rabbit
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Target Species: Human
Applications:
- Immunohistochemistry (IHC)
- Western Blot (WB)
Storage:
Store antibody at -20˚C for up to one year.
Documents
Further Information
Additional Names:
P113, ISGF-3, STAT113, HYRC, HYRC1, P113
Application Note:
Western Blot: 1:500~1:1000, Immunohistochemistry: 1:50~1:100
Background:
STAT2 encoded by this gene is a member of the STAT protein family. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. In response to interferon (IFN), this protein forms a complex with STAT1 and IFN regulatory factor family protein p48 (ISGF3G), in which this protein acts as a transactivator, but lacks the ability to bind DNA directly. Transcription adaptor P300/CBP (EP300/CREBBP) has been shown to interact specifically with this protein, which is thought to be involved in the process of blocking IFN-alpha response by adenovirus.
Background References:
- Fu, X. et al. (1992) Biochemistry 89, 7840-7843. Park, C. et al. (2000) Immunity 13, 795-804. Horvath, C. et al. (1996) Molecular and Cellular Biology 16, 6957-6964. Improta, T. et al. (1994) Proc. Natl. Acad. Sci. USA 91, 4776-4780.
Buffer:
Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Concentration:
1 mg/mL
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Immunogen:
STAT2 (Ab-690) antibody was raised against a peptide sequence around aa.688~692 (R-K-Y-L-K) derived from Human STAT2.
NCBI Gene ID #:
6773
NCBI Official Name:
signal transducer and activator of transcription 2, 113kDa
NCBI Official Symbol:
STAT2
NCBI Organism:
Homo sapiens
Physical State:
Liquid
PREDICTED MOLECULAR WEIGHT:
113 kDa
Protein Accession #:
NP_005410.1
Protein GI Number:
4885615
Purification:
Antibodies were purified by affinity-chromatography using epitope-specific peptide.
Research Area:
Apoptosis,Cancer
SPECIFICITY:
This antibody detects endogenous level of total STAT2 protein.
Swissprot #:
P52630