TrkB Antibody
| Code | Size | Price |
|---|
| PSI-79-502-0.1mg | 0.1mg | £488.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Rabbit
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Target Species:
- Human
- Mouse
- Rat
Application: Western Blot (WB)
Storage:
Store antibody at -20˚C for up to one year.
Documents
Further Information
Additional Names:
TRKB, trk-B, GP145-TrkB, P53, BDNF/NT-3 growth factors receptor precursor, EC 2.7.10.1, GP145-TrkB/GP95-TrkB, NTRK2
Application Note:
Western Blot: 1:500~1:1000
Background:
Receptor for brain-derived neurotrophic factor (BDNF), neurotrophin-3 and neurotrophin-4/5 but not nerve growth factor (NGF). Involved in the development and/or maintenance of the nervous system. This is a tyrosine-protein kinase receptor. Known substrates for the TRK receptors are SHC1, PI-3 kinase, and PLC γ1.
Background References:
- Woronowicz A, et al. Glycobiology. 2007 Jan;17 (1): 10-24. Mojsilovic-Petrovic J, et al. J Neurosci. 2006 Sep 6;26 (36): 9250-63. Lewis MA, et al. Mol Pharmacol. 2006 Apr;69 (4): 1396-404. Cai D, et al. Physiol Genomics. 2006 Feb 14;24 (3): 191-7.
Buffer:
Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Concentration:
1 mg/mL
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Immunogen:
TrkB (Phospho-Tyr705) antibody was raised against a peptide sequence around phosphorylation site of tyrosine 705 (T-D-Y P-Y-R) derived from Human TrkB.
Modifications:
Phospho-Specific
NCBI Gene ID #:
4915
NCBI Official Name:
neurotrophic tyrosine kinase, receptor, type 2
NCBI Official Symbol:
NTRK2
NCBI Organism:
Homo sapiens
Physical State:
Liquid
PREDICTED MOLECULAR WEIGHT:
140 kDa
Protein Accession #:
NP_001007098.1
Protein GI Number:
55956790
Purification:
Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy using non-phosphopeptide.
Research Area:
Phospho-Specific,Neuroscience
SPECIFICITY:
This antibody detects endogenous level of TrkB only when phosphorylated at tyrosine 705.
Swissprot #:
Q16620