FAS Antibody
| Code | Size | Price |
|---|
| PSI-XW-7192-0.05mg | 0.05mg | £765.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Chicken
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Target Species:
- Human
- Mouse
- Rat
Application: Western Blot (WB)
Storage:
FAS antibody can be stored at 4˚C for short term (weeks). Long term storage should be at -20˚C. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Documents
Further Information
Additional Names:
APT1, FAS1, TNFRSF6, Tumor necrosis factor receptor superfamily member 6, Apo-1 antigen, APT1, CD95, APO-1, FASTM, ALPS1A, RP11-399O19.9, FAS (N145)
Application Note:
FAS (N-145) antibody can be used for the detection of FAS (N-145) by Western blot, may also work for IHC and ICC.
Background:
Tumor necrosis factor receptor superfamily, member 6 isoform 1; apoptosis antigen 1; Fas antigen; APO-1 cell surface antigen. This protein is a member of the TNF-receptor superfamily. This receptor contains a death domain. It has been shown to play a central role in the physiological regulation of programmed cell death, and has been implicated in the pathogenesis of various malignancies and diseases of the immune system. The interaction of this receptor with its ligand allows the formation of a death-inducing signaling complex that includes Fas-associated death domain protein (FADD), caspase 8, and caspase 10. The autoproteolytic processing of the caspases in the complex triggers a downstream caspase cascade, and leads to apoptosis. This receptor has been also shown to activate NF-κB, MAPK3/ERK1, and MAPK8/JNK, and is found to be involved in transducing the proliferating signals in normal diploid fibroblast and T cells. At least eight alternatively spliced transcript variants encoding seven distinct isoforms have been described. The isoforms lacking the transmembrane domain may negatively regulate the apoptosis mediated by the full length isoform. ** Cat.N
Background References:
- Brunner, T. et al : Cell-autonomous Fas (CD95)/Fas-ligand interaction mediates activation-induced apoptosis in T-cell hybridomas. Nature 373: 441-444, 1995.
Buffer:
Phosphate-Buffered Saline. No preservatives added.
Concentration:
1 mg/mL
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Immunogen:
21-165
NCBI Gene ID #:
355
NCBI Official Name:
Fas cell surface death receptor
NCBI Official Symbol:
FAS
NCBI Organism:
Homo sapiens
Physical State:
Liquid
PREDICTED MOLECULAR WEIGHT:
37.7 kDa (calculated)
Protein Accession #:
NP_000034.1
Protein GI Number:
4507583
Purification:
Antigen affinity-purified
Research Area:
Apoptosis, Neuroscience
Swissprot #:
P25445
User NOte:
Optimal dilutions for each application to be determined by the researcher.