MARCH1 Antibody

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ProSci
Product Code: PSI-25-837
Product Group: Primary Antibodies
Supplier: ProSci
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PSI-25-837-100ul100ul£662.00
Quantity:
Prices exclude any Taxes / VAT

Overview

Host Type: Rabbit
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Target Species:
  • Human
  • Mouse
  • Rat
Applications:
  • Enzyme-Linked Immunosorbent Assay (ELISA)
  • Western Blot (WB)
Storage:
For short periods of storage (days) store at 4˚C. For longer periods of storage, store MARCH1 antibody at -20˚C. As with any antibody avoid repeat freeze-thaw cycles.

Images

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Antibody used in WB on Human Muscle at 0.2-1 ug/ml.
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Antibody used in WB on Human Muscle at 0.2-1 ug/ml.

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Further Information

Additional Names:
MARCH1, DKFZp564M1682, FLJ20668, MARCH-I, RNF171
Application Note:
MARCH1 antibody can be used for detection of 40238 by ELISA at 1:1562500. MARCH1 antibody can be used for detection of 40238 by western blot at 1 μg/mL, and HRP conjugated secondary antibody should be diluted 1:50,000 - 100,000.
Background:
MARCH1 is an E3 ubiquitin-protein ligase that may mediate ubiquitination of TFRC, CD86 and FAS, and promote their subsequent endocytosis and sorting to lysosomes via multivesicular bodies. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfer the ubiquitin to targeted substrates.
Background References:
  • De (2008) Proc. Natl. Acad. Sci. U.S.A. 105 (9), 3491-3496.
Buffer:
Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
Concentration:
batch dependent
Conjugate:
Unconjugated
Immunogen:
Antibody produced in rabbits immunized with a synthetic peptide corresponding a region of human MARCH1.
NCBI Gene ID #:
55016
NCBI Official Name:
membrane-associated ring finger (C3HC4) 1, E3 ubiquitin protein ligase
NCBI Official Symbol:
Mar-01
NCBI Organism:
Homo sapiens
Physical State:
Liquid
PREDICTED MOLECULAR WEIGHT:
31 kDa
Protein Accession #:
NP_060393
Protein GI Number:
8923613
Purification:
Antibody is purified by peptide affinity chromatography method.
Research Area:
Membrane
Swissprot #:
Q8TCQ1-2
User NOte:
Optimal dilutions for each application to be determined by the researcher.