Further Information
HSD11B1, 11-DH, 11-beta-HSD1, HDL, HSD11, HSD11B, HSD11L, MGC13539, CORTRD2, SDR26C1
HSD11B1 antibody can be used for detection of HSD11B1 by ELISA at 1:312500. HSD11B1 antibody can be used for detection of HSD11B1 by western blot at 1 μg/mL, and HRP conjugated secondary antibody should be diluted 1:50,000 - 100,000.
HSD11B1 is a microsomal enzyme that catalyzes the conversion of the stress hormone cortisol to the inactive metabolite cortisone. In addition, HSD11B1 can catalyze the reverse reaction, the conversion of cortisone to cortisol. Too much cortisol can lead to central obesity, and a particular variation in this gene has been associated with obesity and insulin resistance in children.The protein encoded by this gene is a microsomal enzyme that catalyzes the conversion of the stress hormone cortisol to the inactive metabolite cortisone. In addition, the encoded protein can catalyze the reverse reaction, the conversion of cortisone to cortisol. Too much cortisol can lead to central obesity, and a particular variation in this gene has been associated with obesity and insulin resistance in children. Two transcript variants encoding the same protein have been found for this gene.
- Paulsen, S.K., (2008) Obesity (Silver Spring) 16 (4), 731-735.
Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
batch dependent
Unconjugated
Antibody produced in rabbits immunized with a synthetic peptide corresponding a region of human HSD11B1.
3290
hydroxysteroid (11-beta) dehydrogenase 1
HSD11B1
Homo sapiens
Liquid
PREDICTED MOLECULAR WEIGHT:
32 kDa
NP_005516
5031765
Antibody is purified by peptide affinity chromatography method.
Membrane ,Cancer ,Signal Transduction
P28845
Optimal dilutions for each application to be determined by the researcher.